Oral Presentations

Title: Gene Therapy in Fanconi Anemia: Looking for efficient and safe gene editing approaches
Speakers: Paula Río
Date: April 1st, 2022
Place: Bordeaux, France
Organizing institucion: CRISPR AND TRANSLATIONNAL MEDICINE CONGRESS

Title: Moving from basic stem cell research to clinical gene therapy?
Speakers: J. Bueren
Date: April 27-29, 2022
Place: Athens, Greece
Organizing institucion: ESGCT SPRING SCHOOL 2021 - Postponed ti March 2021

Title: Keynote lecture: Gene therapy in Fanconi Anemia 
Speakers: J. Bueren
Date: April 7-9, 2022
Place: Rome, Italy
Organizing institucion: EHA-SWG Scientific Meeting "the Blood and the Child - New Insights in Pediatric Benign Hematology

Title: Closing keynote: Gene therapy in hematopoietic stem cell diseases: The Fanconi anemia model
Speakers: J. Bueren
Date: March 16-19, 2022
Place: Lyon, France
Organizing institucion: SFTCG Annual Meeting

Title: Un año de Nobel para las Terapias Avanzadas. Lecciones aprendidas, promesas de futuro
Speakers: Juan A. Bueren
Date: November, 10-11, 2021
Place: ONLINE
Organizing institucion: AMIFE XIV CONGRESO

Title: Follow-Up of a Phase I/II Gene Therapy Trial in Patients with Fanconi Anemia, Subtype A
Speakers: Juan A. Bueren
Date: May 11-14, 2021
Place: ONLINE
Organizing institucion: ASGCT 24th

Title: LV-Mediated Gene Therapy of Pyruvate Kinase Deficiency
Speakers: Jose C. Segovia
Date: May 11-14, 2021
Place: ONLINE
Organizing institucion: ASGCT 24th

Title: Gene Therapy in Fanconi Anemia: Current Strategies to Enable the Correction of HSCs
Speakers: Paula Río
Date: May 11-14, 2021
Place: ONLINE
Organizing institucion: ASGCT 24th

Title: Estrategias de Terapia Génica para el tratamiento de pacientes con Anemia de Fanconi.
Speakers: Paula Río
Date: March 24-26, 2021
Place: ONLINE
Organizing institucion: SEI-42. Congreso Sociedad Española de Inmunología.

Title: MSC con sobreexpresión de CXCR4 e IL-10.
Speakers: Rosa Yañez
Date: Jannuary 21, 2021
Place: ONLINE
Organizing institucion: Reunión Técnica TerCel 2021. INGENIERIA CELULAR ENCÉLULAS MESENQUIMALES (MSC 2.0)

Title: Clonal Tracking Post-Gene Therapy for Fanconi Anemia.
Speakers: Paula Río
Date: December 5-8, 2020
Place: ONLINE
Organizing institucion: 62nd ASH  Annual Meeting and Exposition.

Title: Terapia génica: expectativas.
Speakers: Juan A. Bueren
Date: November 24-26, 2020
Place: ONLINE
Organizing institucion: XIII CONGRESO INTERNACIONAL DE ENFERMEDADES RARAS

Title: Gene therapy for Fanconi anaemia.
Speakers: Juan A. Bueren
Date: November 13-15, 2020.
Place: ONLINE
Organizing institucion: Bone marrow failure disorders. ESH - European School of Haematology.

Title: Academic perspective
Speakers: Juan A. Bueren
Date: November 30,  2020
Place: ONLINE
Organizing institucion: Support for development of orphan medicines. Incentives, scientific advice, and funding schemes. EUROPEAN MEDICINES AGENCY.

Title: Terapia génica en hematología: el modelo de la anemia de Fanconi
Speakers: Paula Río
Date: October 26-30, 2020
Place: ONLINE
Organizing institucion: LXII congreso nacional SEHH - XXXVI Congreso nacional SETH

Title: Gene Therapy for Fanconi anemia: From the lab to the clinic.
Speakers: Paula Río
Date: October 26-29, 2020
Place: VIRTUAL - Weizmann Institute of Science, Israel
Organizing institucion: The 16th transgenic technology meeting.

Title: Update of Phase I/II Gene Therapy Trial in Fanconi Anemia Patients, subtype A.
Speakers: Paula Río
Date: September 15-14, 2020
Place: ONLINE
Organizing institucion: 32nd Annual Fanconi Anemia Scientific Symposium.

Title: From preclinical to clinical trials in gene therapies.
Speakers: Juan A. Bueren
Date: August 31, 2020
Place: ONLINE
Organizing institucion: Advanced Therapies” UIMP Summer School 2020.

Title: Therapeutic Gene Editing Strategies in Fanconi Anemia
Speakers: Paula Río
Date: May 28-29 , 2020
Place:Virtual - Paris
Organizing institucion: International Society of Cell Therapy-Virtual-Accelerating Cell & Gene Therapy Adoption. Proff of Concept to Standard of Care

Title: Update on the ongoing trial in Europe
Speakers: Paula Río
Date: May 1, 2020
Place: ONLINE
Organizing institucion: FANCONI ANEMIA RESEARCH FUND.

Title: Ongoing gene therapy trials in FA: update on the ongoing trial in Europe
Speakers: Paula Río
Date: May 1, 2020
Place: ONLINE
Organizing institucion: Gene Therapy in Fanconi Anemia-Fanconi Anemia Research Fund

Title: Gene therapy in Fanconi anemia (FA)
Speakers: J. Bueren
Date: October 10-12, 2019
Place: Prague, Czesh Republic
Organizing institucion: Stem Cell transplantation in childhood biotechnological advances, ethical issues and worldwide equal access

Title: Stem Cell transplantation in childhood biotechnological advances, ethical issues and worldwide equal access
Speakers: J. Bueren
Date: 26-28 september 2019
Place: Roma, Italy
Organizing institucion: Stem Cell transplantation in childhood biotechnological advances, ethical issues and worldwide equal access

Title: NHEJ-mediated gene editing: an alternative approach to efficiently correct hspcs from patients with fanconi anemia
Speakers: P. Río
Date: 12 september 2019
Place: Madison, WI, USA
Organizing institucion: ISCT

Title: Lentiviral gene therapy and genome editing for the treatment of a rare hemolytic disease, Pyruvate Kinase Deficiency
Speakers: Jose Carlos Segovia
Date: july 14 2019
Place: Barcelona, Spain
Organizing institucion: CRG y upf

Title: Gene Therapy Panel
Speakers: P. Río
Date: 21-26 June 2019
Place: Camp Sunshine, Casco, Maine
Organizing institucion: 28th Annual Family Meeting

Title: Pyruvate kinase deficiency gene therapy.
Speakers: Jose Carlos Segovia
Date: may 17 2019
Place: Athens, Greece
Organizing institucion: 4th Congress gene therapy and regenerative medicine

Title: Genome-wide assessment of lentiviral integration sites of gene-corrected lympho-hematopoietic cells in FA-A patients
Speakers: S. Navarro
Date: april 29-may 2 2019
Place: Washington D.C., USA
Organizing institucion: 22nd Annual Meeting of the American Society of Gene and Cell Therapy

Title: Update on the Fanconi anaemia clinical trial
Speakers: P. Río
Date: 17 May 2019
Place: Paris, France
Organizing institucion: SFTCG: Societe francaise de therapie cellulaire et genique

Title: Preliminary conclusions obtained in Fanconi anemia patients treated by lentiviral-mediated gene therapy after 2 years of follow-up
Speakers: Paula Rio
Date: April 29-May 2 2019
Place: Washington D.C., USA
Organizing institucion: 22nd Annual Meeting of the American Society of Gene and Cell Therapy

Title: Advanced therapies for the treatment of PH1: cellular reprogramming and gene editing
Speakers: Virginia Nieto Romero
Date: 21-22 june 2019
Place: Boston, EEUU.
Organizing institucion: OHF International Hyperoxaluria Workshop

Title: Preclinical Studies towards the Gene Therapy of Diamond-Blackfan Anemia
Speakers: Susana Navarro
Date: 10-12 june 2019
Place: Amsterdam, Holland.
Organizing institucion: The european Diamond-Blackfan anemia symposium

Title: Efficient genome editing of the PKLR locus in human long-term hematopietic stem cells using specific CRISPR/CAS9 RNP and AAV6-delivery of donor templates to treat pyruvate kinase deficiency
Speakers: S. Fañanas Baquero
Date: April 29-May 2 2019
Place: Washington, D.C., USA
Organizing institucion: 22nd Annual Meeting of the American Society of Gene and Cell Therapy

Title: Gene therapy for bone marrow failure syndromes
Speakers: J. Bueren
Date: April 26th 2019
Place: Zürich, Switzerland.
Organizing institucion: INTERNATIONAL SYMPOSIUM GENE AND CELL THERAPIES

Title: Fanconi Anaemia and other inherited bone marrow failure syndromes
Speakers: J. Bueren
Date: 22-25 march 2019
Place: Madrid, Spain.
Organizing institucion: 46th Annual meeting of the european society for blood and marrow transplantation

Title: Conferences on haematological diseases
Speakers: J. Bueren
Date: 7 february 2019
Place: Paris, France
Organizing institucion: Gene Therapy for Rare monogenic Diseases (GTRD)-1st EDITION

Title: Therapie genique dans I`Anemia de Fanconi
Speakers: J. Bueren
Date: 24-25 Jannuary 2019
Place: Chamonix, France
Organizing institucion: CONGRES SOCIETE D`HEMATOLOGIE ET D`IMMUNOLOGIE PEDIATRIQUE

Title: NHEJ-mediated editing in FA HSCs
Speaker: Francisco Jose Román Rodriguez
Date: 25-28 october 2018
Place: Seville, Spain
Organizing institución: 9th Annual Meeting of the International Fanconi Anaemia Gene Therapy Working Group

Title: Updated results of the FA gene therapy trial in Spain (FANCOLEN-I): genotype/phenotype changes in treated patients.
Speaker: Paula Río.
Date: 25-28 octuber 2018
Place: Seville, Spain
Organizing institución: 9th Annual Meeting of the International Fanconi Anaemia Gene Therapy Working Group

Title: Efficacy of filgrastim and plerixafor in the mobilization of HSCs in FA patients: Preliminary conclusions of the FANCOSTEM clinical trial
Speaker: Susana Navarro.
Date: 25-28 octuber 2018
Place: Seville, Spain
Organizing institución: 9th Annual Meeting of the International Fanconi Anaemia Gene Therapy Working Group

Title: Terapia génica para enfermedades raras: Una realidad.
Speaker: Jose Carlos Segovia.
Date: 24-26 october 2018
Place: Bilbao, España
Organizing institución: LABCLIN - XII Congreso nacional del laboratorio clinico

Title: Gene therapy in bone marrow failure syndromes.
Speaker: Juan Bueren.
Date: 16-19 october 2018
Place: LAUSANNE, SWISSTECH
Organizing institución: EHA- CHANGING THE FACE OF MODERN MEDICINE: STEM CELLS & GENE THERAPY.

Title: Gene therapy trial in non-conditioned Fanconi anemia patients.
Speaker: Paula Río.
Date: 16-19 october 2018
Place: LAUSANNE, SWISSTECH
Organizing institución: EHA- CHANGING THE FACE OF MODERN MEDICINE: STEM CELLS & GENE THERAPY

Title: Comprehensive preclinical studies for the gene therapy of patients with leukocyte adhesion deficiency type I (LAD-I)
Speaker: Elena Almarza.
Date: 16-19 october 2018
Place: LAUSANNE, SWISSTECH
Organizing institución: EHA- CHANGING THE FACE OF MODERN MEDICINE: STEM CELLS & GENE THERAPY

Title: Salas GMP: Requerimientos para la fabricación de Medicamentos de Terapias Avanzadas.
Speaker: Rosa Yáñez.
Date: 8 october 2018
Place: UAM-MADRID, SPAIN
Organizing institución: VISION PRESENTE Y FUTURA DE LA TERAPIA GENICA: ENFOQUE DE 360º

Title: Modelo preclínico de terapia génica para el tratamiento de la deficiencia de adhesión leucocitaria tipo I
Speaker: Cristina Mesa Nuñez
Date: 4 october 2018
Place: CIEMAT-MADRID, Spain
Organizing institución: CIEMAT - CICLO DE SEMINARIOS DE JOVENES INVESTIGADORES

Title: Gene editing to cure hematopoietic inherited diseases. The gene therapy 2.0
Speaker: Jose Carlos Segovia
Date: 25-27 september 2018
Place: Seville, Spain
Organizing institución: Biospain 2018 -9th international meeting on biotechnology

Title: Role play by galectin-1 in regulatory T-cell immunotherapy for modulation of immune responses in the treatment of autoimmune diseases
Speaker: Raquel Fernandéz Pérez
Date: 15 september 2018
Place: Madrid, Spain
Organizing institución: ICLE 2018: INTERNATIONAL CONFERENCE ON LYMPHOCYTE ENGINEERING

Title: Flow cytometry networking and interactions
Speaker: Jose Carlos Segovia
Date: 15 september 2018
Place: Valencia, Spain
Organizing institución: ESCCA 2018 At the shore of future cytometry

Title: Genetical manipulation of MSC to improve function.
Speaker: Rosa María Yañez González
Date: 4 july 2018
Place: Los Alcazares, Murcia, Spain
Organizing institución: 35 edición Cursos de Verano "CELL THERAPY FROM THE BENCH TO THE BEDSIDE AND RETURN", (UNIMAR)

Title: Gene editing: A New tool for the future
Speaker: Jose Carlos Segovia
Date: 4 july 2018
Place: Los Alcazares, Murcia, Spain
Organizing institución: 35 edición Cursos de Verano "CELL THERAPY FROM THE BENCH TO THE BEDSIDE AND RETURN", (UNIMAR)

Title: Gene Therapy: clinical developments
Speaker: Juan Bueren
Date: 6 july 2018
Place: Los Alcazares, Murcia, Spain
Organizing institución: 35 edición Cursos de Verano "CELL THERAPY FROM THE BENCH TO THE BEDSIDE AND RETURN", (UNIMAR)

Title: Presente y Futuro de la Terapia Génica
Speaker: Juan Bueren
Date: 14 jun 2018
Place: Madrid, Spain
Organizing institución: XXXIV Congreso Sociedad Andaluza de Medicina Interna (SADEMI)

Title: Avances en la terapia génica de pacientes con anemia de Fanconi
Speaker: Juan Bueren
Date: 5 jun 2018
Place: Madrid, Spain
Organizing institución: Fundacion Sermes

Title: Retos y oportunidades para la Investigacion clínica en España. Visión de un investigador
Speaker: Juan Bueren
Date: 23 may 2018
Place: Madrid, Spain
Organizing institución: Agencia española de medicamentos y productos sanitarios. Ministerio de Sanidad, Servicios Sociales e Igualdad

Title: Generation and potential applications of an X-linked dyskeratosis congenita model in human hematopoietic stem cells
Speaker: Carlos Carrascoso Rubio
Date: 18 may 2018
Place: Madrid, Spain
Organizing institución: 1st PhD Research Symposium in Health Sciences and Biomedicine

Title: Preclinical safety and efficacy evaluation of lentivirally transduced hematopoietic stem cells for the treatment of leukocyte adhesion deficiency type I
Speaker: Cristina Mesa Núñez
Date: 18 may 2018
Place: Madrid, Spain
Organizing institución: 1st PhD Research Symposium in Health Sciences and Biomedicine

Title: Gene Editing in Fanconi anemia hematopoietic stem and progenitor cells
Speaker: Paula Río
Date:  16-19 may 2018
Place: Chicago, Illinois, USA
Organizing institución: 21st Annual Meeting ASGCT

Title: Gene Therapy for Fanconi Anemia
Speaker: Juan Bueren
Date: may 2018
Place: Chicago, EEUU
Organizing institución: ASGCT 21st Annual Meeting

Title: I JORNADAS DE TERAPIAS BIOTECNOLOGICAS: Terapia génica y aplicaciones
Speaker: Paula Rio
Date: april 2018
Place: Salamanca, Spain
Organizing institución: Asociación de Biotecnología de Salamanca

Title: Terapia génica para el tratamiento de la anemia de Fanconi
Speaker: Paula Río 
Date: april 2018
Place: Madrid, SPAIN
Organizing institución: Instituto de Salud Carlos III (ISC)

Title: Terapia génica: un horizonte de aplicaciones(I). Enfermedades hematologicas hereditarias.
Speaker: Guillermo Güenechea
Date: april 2018
Place: Valencia, SPAIN
Organizing institución: TERAPIA GÉNICA Y FARMACIA HOSPITALARIA. VII Encuentro CHIESI

Title: Development and potential applications of a haematopoietic stem cell model of X-linked dyskeratosis congenital.
Speaker:  Carrascoso, Carlos
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title: Gene editing for pyruvate kinase deficiency: Improvements towards its clinical application.
Speaker: S. Fañanas-Baquero
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title: Preclinical studies towards the gene therapy of Diamond-Blackfan anaemia patients
Speaker: Y. Gimenez-Martinez
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title: Efficient gene editing of human haematopietic stem cells
Speaker: F.J. Román-Rodriguez
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title: Enhanced anti-inflammatory potential os mesenchymal stromal cells mediated by the ectopic transient expression of CXCR4 and IL10
Speaker: M.R. Hervas
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title: Preclinical safety and efficacy evaluation of lentiviral transduced haematopoietic stem cells for the treatment of leukocyte adhesion deficiency type I.
Speaker: C. Mesa-Núñez
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title: Resolver problemas de genética… ¿y crear otros de ética? CRISPR-Cas
Speaker: Oscar Quintana
Date: march 2018
Place: Madrid, SPAIN
Organizing institución: BOLHOI – AFTER SCIENCE

Title: Gene editing in Fanconi Anemia hematopoietic stem and progenitor cells
Speaker: Paula Rio
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title:  Ex vivo gene therapy of non conditioned Fanconi anemia patients
Speaker: J Bueren
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title: Gene therapy for pyruvate kinase deficiency.
Speaker: JC Segovia
Date: march 2018
Place: Palma de Mallorca, SPAIN
Organizing institución: SETGYC

Title:  Terapia genica en sindromes congénitos con fallo de médula ósea
Speaker: Juan Bueren
Date: january 2018
Place: Sevilla, SPAIN
Organizing institución: IBIS (Instituto de Biomedicina de Sevilla)

Title:  Edición génica mediada por NHEJ: Una nueva aproximación para corregir diferentes mutaciones en células madre y progenitores hematopoyéticos de Anemia de Fanconi.
Speaker: Paula Rio
Date: january 2018
Place: Madrid, SPAIN
Organizing institución: FUNDACION RAMON ARECES

Title: Generación de modelos celulares de anemias raras mediante CRISPR-Cas9 
Speaker: JC Segovia
Date: january 2018
Place: Madrid, SPAIN
Organizing institución: FUNDACION RAMON ARECES

Title: Bioseguridad de Lentivirus en el contexto de la terapía génica para la anemia de Fanconi
Speaker: Guillermo Güenechea
Date: december 2017
Place: Madrid
Organizing institucion: UNIVERSIDAD COMPLUTENSE DE MADRID: Máster en Virología

Title: Desarrollo de terapia génica para el tratamiento del fallo de médula ósea en disqueratosis congénita
Speaker: Guillermo Güenechea
Date: 21 november 2017
Place: Madrid
Organizing institucion: CNIO-CIBERER: Jornada de investigación cooperativa

Title: Terapia génica dirigida en células madre para la corrección de la deficiencia de piruvato quinasa
Speaker: Oscar Quintana
Date: november 2017
Place: Madrid
Organizing institucion: Universidad Complutense de Madrid

Title: Tratamiento de la Artritis Reumatoide con células madre mesenquimales derivadas del tejido adiposo
Speaker: Marina Garín
Date: november 2017
Place: Madrid
Organizing institucion: Universidad Complutense de Madrid: máster interuniversitario en Genética y Biología Celular

Title: Métodos y procedimientos clínicos en Terapia celular y Diseño de Ensayos Clínicos
Speaker: Mercedes López Santalla
Date: november 2017
Place: Madrid
Organizing institucion: CEU Universidad San Pablo: Máster Universitario en Medicina Regenerativa y Terapia Celular

Title: Métodos y procedimientos clínicos en Terapia celular y Diseño de Ensayos Clínicos
Speaker: Marina Garín
Date: november 2017
Place: Madrid
Organizing institucion: CEU Universidad San Pablo: Máster Universitario en Medicina Regenerativa y Terapia Celular

Title: Direct correction of Fanconi anemia associated mutations in haematopoietic stem and progenitor cells by a novel NHEJ-mediated gene editing approach
Speaker: Roman-Rodriguez, F. J., Diez, B., Alvarez, L., Risueño, C., Torres-Ruiz, R., Corton, M., Ayuso, C., Bueren, J. and Rio, P
Date: 17-20 october 2017
Place: Berlin, GERMANY
Organizing institucion: ESGCT: XXV EUROPEAN SOCIETY OF GENE & CELL THERAPY

Title: Engraftment and repopulation advantage of gene-corrected haematopoietic stem cells in Fanconi anaemia patients
Speaker: Bueren, J.
Date: 17-20 october 2017
Place: Berlin, GERMANY
Organizing institucion: ESGCT: XXV EUROPEAN SOCIETY OF GENE & CELL THERAPY

Title: Engraftment and Repopulation Advantage of Gene-Corrected Hematopoietic Precursors in Non-Conditioned Fanconi Anemia Patients
Speaker: Rio, P, Navarro, S., Guenechea, G., Galy, A., Sanchez-Dominguez, R, Lamana, M., Yañez, R., Gimenez, Y., Román, FJ, Casado, J., Segovia, J C., Surralles, J., Lozano, M., Alvarez, L., Cerrato, L., Hernando, M., Lopez, R., Garcia de Andoain, N., Díaz de Heredia, C., Sevilla, J. and Bueren, J.
Date:  14-17 september 2017
Place: ATLANTA, EEUU
Organizing institucion: 29th ANNUAL FANCONI ANEMIA RESEARCH FUND SCIENTIFIC SYMPOSIUM

Title: NHEJ-mediated Gene Editing: A new approach to correct different mutations in Fanconi Anemia Hematopoietic Stem and Progenitor Cells
Speaker: Román-Rodriguez, F. J., Díez, B., Alvarez, L., Risueño, C., Torres, R., Corton, M., Ayuso, C., Rio, P and Bueren, J.
Date: 14-17 september 2017
Place: ATLANTA, EEUU
Organizing institucion: 29th ANNUAL FANCONI ANEMIA RESEARCH FUND SCIENTIFIC SYMPOSIUM

Title: Preliminary conclusions of a clinical trial for the mobilization of hematopoietic stem cells from Fanconi anemia patients with Plerixafor and Filgrastim
Speaker: : Navarro, S., Rio, P, Sanchez-Dominguez, R, Alberquilla, O., Casado, J., Pujol, R., Merino, E., Surralles, J., Lopez, R., Garcia de Andoain, N., Ruiz, P., Catala, A., Segovia, J C., Díaz de Heredia, C., Sevilla, J. and Bueren, J.
Date: 14-17 september 2017
Place: ATLANTA, EEUU
Organizing institucion: 29th ANNUAL FANCONI ANEMIA RESEARCH FUND SCIENTIFIC SYMPOSIUM

Title: New strategies for cell and gene therapy in primary hyperoxaluria type 1
Speaker: Garcia-Bravo, M
Date: july 2017
Place: Puerto de la Cruz, Tenerife, Spain
Organizing institucion: 12th International Primary Hyperoxaluria Workshop for Professionals, Patients and Families

Title: Ejemplo práctico de CRISPR en terapia génica con células primarias.
Speaker: Oscar Quintana
Date: july 2017
Place: Madrid
Organizing institucion: Centro nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco.

Title: Los Sistemas CRISPR en diseños experimentales de terapia génica
Speaker: Oscar Quintana
Date: july 2017
Place: Madrid
Organizing institucion: Centro nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco.

Title: MEASLES VIRUS GLYCOPROTEIN PSEUDOTYPED LENTIVIRAL VECTORS EFFICIENTLY TRANSDUCE UNFRACTIONATED BONE MARROW AND MOVILIZED PERIPHERAL BLOOD HEMATOPOIETIC STEM AND PROGENITOR CELLS FROM FANCONI ANEMIA PATIENTS
Speaker: Roman-Rodriguez, F. J., Levy, C., Bernadin, O., Costa, C., Díez, B., Alvarez, L., Verhoeyen, E., Bueren, J. A. and Rio, P.
Date: june 2017
Place: Madrid, Spain
Organizing institucion: VIII International Congress of the Spanish Research Network on Fanconi Anemia

Title: NHEJ-based gene editing: A novel gene therapy approach in Fanconi anemia hematopoietic stem cells
Speaker: Roman-Rodriguez, F. J.
Date: june 2017
Place: Madrid, Spain
Organizing institucion: Young EHA Research Meeting on Molecular Aspects of Hematological Disorders

Title: GENE EDITING STRATEGIES IN HEMATOPOIETIC CELLS FROM FA PATIENTS
Speaker: Rio, P., Roman-Rodriguez, J., Diez, B., Alvarez, L., Risueño, C., Torres-Ruiz, R., Corton, M., Ayuso, C. and Bueren, J. A.
Date: june 2017
Place: Madrid, 2017
Organizing institucion: VIII International Congress of the Spanish Research Network on Fanconi anemia

Title: Efficient mobilization of hematopoietic stem and progenitors cells from Fanconi anemia patients with plerixafor and filgastrim
Speaker: Navarro, S., Rio, P., Sanchez, R., Alberquilla, O., Casado, J., Pujol, R., Surralles, J., Lopez, R., Garcia de Andoain, N., Ruiz, P., Catala, A., Segovia, J C., Diaz de Heredia, C., Sevilla, J. and Bueren, J.
Date: june 2017
Place: Madrid SPAIN
Organizing institucion:  VIII International Congress of the Spanish Research Network on Fanconi Anemia

Title: Generation of a cellular model of pyruvate kinase deficiency using the CRISPR/CAS9 gene editing system
Speaker: Lopez-Manzaneda, S.
Date: june 2017
Place: Madrid SPAIN
Organizing institucion: Young EHA Research Meeting on Molecular Aspects of Hematological Disorders

Title: Drug repurposing in Fanconi anemia therapeutics
Speaker: Ramirez, M., Montanuy, H., Casado, J. A., Rio, P., Bueren, J., Minguillón, J. and Surralles, J.
Date: june 2017
Place: : Madrid-Spain
Organizing institucion: VIII International Congress of the Spanish Research Network on Fanconi Anemia

Title: Mesenchymal stroma cells prevent graft failure in Fanconi anemia mouse model of hematopoietic stem cells gene therapy
Speaker: Fernandez-Garcia, M., Lamana, M. L., Sanchez-Dominguez, R., Hernando, M., Bueren, J. A. and Yanez, R.
Date: june 2017
Place: Madrid 2017
Organizing institucion: VIII International Congress of the Spanish Research Network on Fanconi Anemia

Title: A new platform for the registry of Fanconi anemia patients in Spain
Speaker: Casado, J. A., de la Cal, A., Bailador, A., Sanchez, A., Gonzalez, C. and Bueren, J. A.
Date: june 2017
Place: Madrid SPAIN
Organizing institucion: VIII International Congress of the Spanish Research Network on Fanconi Anemia

Title: Engraftment and repopulation advantage of gene-corrected hematopoietic precursors in non-conditioned Fanconi anemia patients
Speaker: Bueren, J. A., Rio, P., Navarro, S., Guenechea, G., Galy, A., Sanchez, R., Lamana, M. L., Yanez, R., Casado, J., Segovia, J. C., Surralles, J., Lozano, M., Alvarez, L., Cerrato, L., Hernando, M., Merino, E., Lopez, R., Garcia de Andoain, N., Ruiz, P., Catala, A., Diaz de Heredia, C. and Sevilla, J.
Date: 29-30 june 2017
Place: Madrid SPAIN
Organizing institucion: VIII International Congress of the Spanish Research Network on Fanconi Anemia

Title: Fanconi Anemia: Molecular diagnosis by whole exome secuencing of a cohort of 60 patients
Speaker: Bueren, J. A., Bogliolo, M., Aza, M., Muñoz, N., Pujol, R., Garcia, F., Casado, J. A., Paprotka, T., Bauser, C., Dopazo, J. and Surralles, J.
Date: june 2017
Place: Madrid, SPAIN
Organizing institucion: VIII International Congress of the Spanish Research Network on Fanconi Anemia

Title: FIRST EVIDENCE DEMONSTRATING ENGRAFTMENT AND REPOPULATION ADVANTAGE OF GENE-CORRECTED HEMATOPOIETIC REPOPULATING CELLS IN NON-CONDITIONED FANCONI ANEMIA PATIENTS
Speaker: Sevilla, J., Rio, P., Navarro, S., Galvez, E., Sebastian, E., Guenechea, G., Sanchez, R., Catala, A., Surralles, J., Mavilio, F., Lamana, M. L., Yanez, R., Lopez, R., Galy, A., Casado, J. A., Segovia, J. C., de Andoin, N. G., Ruiz, P., de Heredia, C. D. and Bueren, J.
Date: june 2017
Place: Madrid, SPAIN
Organizing institucion: 22nd Congress of the European-Hematology-Association

Title: Towards the gene therapy of LAD-1 inmunodeficient patients
Speaker: Almarza, E., Mesa-Nuñez, C., León-Rico, D., Aldea, M., Damian, C. and Bueren, J. A.
Date: may 2017
Place: Zaragoza, SPAIN
Organizing institucion: 40 Congreso de la Sociedad Española de Inmunología

Title: First Evidence of Engraftment and Repopulation Advantage of Gene-Corrected Hematopoietic Precursors in Non-Conditioned Fanconi Anemia Patients
Speaker: Rio, P., Navarro, S., Guenechea, G., Galy, A., Sanchez, R., Lamana, M. L., Yanez, R., Casado, J. A., Segovia, J. C., Surralles, J., Lopez, R., De Andoain, N. G., Ruiz, P., Catala, A., Mavilio, F., De Heredia, C. D., Sevilla, J. and Bueren, J. A.
Date: may 2017
Place: Washington, DC
Organizing institucion: 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT)

Title: TERAPIA GENÍCA DIRIGIDA POR CRISPR
Speaker: Segovia, J C.
Date: april 2017
Place: Madrid, SPAIN
Organizing institucion: I CONGRESO INTERDISCIPLIAR EN GENÉTICA HUMANA

Title: Bone Marrow Failure Syndromes
Speaker: Bueren, J.
Date: april 2017
Place: Granada SPAIN
Organizing institucion: European Society of Gene and Cell Therapy: Spring School 2017

Title: Integrative viral vectors
Speaker: Guenechea, G.
Date: 5-7 april 2017
Place: Granada, SPAIN
Organizing institucion: GENYO-FACULTAD DE MEDICINA-UNIVERSIDAD DE GRANADA: European Society of Gene and Cell Therapy: Spring School 2017

Title: Gene editing
Speaker: Rio, P.
Date: april 2017
Place: GRANADA, SPAIN
Organizing institucion: GENYO-FACULTAD DE MEDICINA-UNIVERSIDAD DE GRANADA: Spring School 2017

Title: Key-note: Biosafety in gene therapy
Speaker: Guenechea, G.
Date: april 2017
Place: Madrid 2017
Organizing institucion: 20th ANNUAL CONFERENCE OF THE EUROPEAN BIOSAFETY ASSOCIATION

Title: Primeras evidencias de reconstitución y ventaja proliferativa de células madre hematopoyéticas corregidas por terapia génica en pacientes con anemia de Fanconi
Speaker: Río, P., Navarro, S., Guenechea, G., Galy, A., Sánchez, R., Lamana, M. L., Yañez, R., Casado, J. A., Segovia, J. C., Surrallés, J., López, R., García de Andoaín, N., Ruiz, P., Catalá, A., Mavilio, F., Díaz de Heredia, C., Sevilla, J. and Bueren, J. A.
Date: 23-24 march 2017
Place: El Escorial (Madrid), España
Organizing institucion: X Reunión Anual CIBERER

Title: Thérapie génique du déficit en pyruvate kinase
Speaker: Segovia, J. C
Date: 15-17 march, 2017
Place: Paris, France
Organizing institucion: SFH: 37 Congrés de la Société Française d'Hématologie

Title: Terapia Génica para la anemia de Fanconi
Speaker: Paula Rio
Date: February 2017
Place: Málaga
Organizing institucion: Universidad de Málaga: Día mundial de las enfermedades raras

Title: Key-note: Biosafety in gene therapy
Speaker: G. Güenechea
Date: 21 january 2017
Place: Madrid 2017
Organizing institucion: EBSA: 20th annual Conference of the European Biosafety Association

Title: Terapia Génica en Anemia de Fanconi
Speaker: J. Bueren
Date:13 january 2017
Place: Madrid 2017
Organizing institucion: TERCEL-ISCIII: Reunión técnica TerCel: Ingenieria Celular Terapeútica.

Title: Novedades en la tecnología CRISPR
Speaker: Segovia, J C.
Date: 13 january 2017
Place: Madrid, SPAIN
Organizing institucion: TERCEL-ISCIII: Reunión técnica TerCel: Ingenieria Celular Terapeútica.

Title: Reprogramación y edición génica como alternativa terapéutica para una enfermedad hepato-renal, la hiperoxaluria primaria
Speaker: María García Bravo
Date: november 2016
Place: Alicante, Spain
Organizing institution: TerCel isciii: Reunión anual. Red de Terapia Celular

Title: Lentiviral-mediated gene therapy in Fanconi anemia A:preclinical and first clinical studies
Speaker: S. Navarro
Date: october 2016
Place: Florence, Italy
Organizing institution: ISSCR: Changing the Face of Modern Medicine: Stem Cells and Gene Therapy

Title: Mesenchymal stromal cells prevent graft failure in a mouse model of hematopoietic stem cell gene therapy
Speaker: M Fernandez-Garcia
Date: october 2016
Place: Florence, Italy
Organizing institution: ISSCR: Changing the Face of Modern Medicine: Stem Cells and Gene Therapy

Title: NHEJ-Mediated Gene Editing in Fanconi Anemia Hematopoietic Cells
Speaker: Roman-Rodriguez, F., Diez, B., Alvarez, L., Torres-Ruiz, R., Corton, M., Ayuso, C., Bueren, J. and Rio, P
Date: September 2016
Place: Washington, EEUU
Organizing institution: 28th Annual Fanconi Anemia Research Fund Scientific Symposium

Title: Preclinical and Clinical Studies of Lentiviral-Mediated Gene Therapy with Plerixafor and G-CSF-Mobilized CD34+ Cels in FA-A Patients
Speaker: Rio, P, Navarro, S., Guenechea, G., Galy, A., Sanchez, R., Lamana, M., Yañez, R., Casado, J., Segovia, J C., Surralles, J., Alvarez, L., Cerrato, L., Hernando, M., Merino, E., Ruiz, P., Lopez, R., Garcia de Andoain, N., Haldun, R., Catala, A., Diaz de Heredia, C., Sevilla, J. and Bueren, J.
Date: september 2016
Place: Washington, EEUU
Organizing institution: 28th Annual Fanconi Anemia Research Fund Scientific Symposium

Title: Clonal Mosaicism as Biomarker of Cancer Risk and Cancer-Free Survival in Fanconi Anemia
Speaker: Reina, J., Pujol, R., Lopez-Sanchez, M., Rodriguez-Santiago, Benjamin., Aza-Carmona, M., Gonzalez, JR., Casado, J., Bueren, J., Sevilla, J., Badell, I., Catala, A., Belendez, C., Dasí, A., Diaz de Heredia, C., Soulier, J., Schindler, D., Perez-Jurado, LA. and Surralles, J.
Date: September 2016
Place: Washington, EEUU
Organizing institution: 28th Annual Fanconi Anemia Research Fund Scientific Symposium

Title: iPSC and Gene Therapy for Genetic Diseases
Speaker: Bueren, J.
Date: July 2016
Place: Los Alcázares
Organizing institution: Cell Therapy. From the Bench to the Bedside and Return

Title: Aproximaciones de Terapia Génica en Anemia de Fanconi
Speaker: Bueren, J.
Date: June 2016
Place: Bilbao
Organizing institution: 27 Congreso Anual de la SETS

Title: Lentiviral-Mediated Gene Correction of Mobilized Peripheral Blood Progenitors and Repopulating Cells from FA-A Patients
Speaker: Rio, P, Navarro, S., Guenechea, G., Galy, A., Sanchez, R., Lamana, M., Yañez, R., Casado, JA., Segovia, J C., Surralles, J., López, R., Garcia de Andoain, N., Ruiz, P., Catala, A., Diaz de Heredia, C., Sevilla, J. and Bueren, J.
Date: May 2016
Place: Washington, EEUU
Organizing institution: ASGCT 19Th Annual Meeting

Title: Gene therapy in Fanconi anemia
Speaker: Bueren, J.
Date: May 2016
Place: Barcelona
Organizing institution: ESHG

Title: Avances en la Aplicación de Terapias Innovadoras-Terapia Génica en Anemia de Fanconi
Speaker: Bueren, J.
Date: May 2016
Place: Santander
Organizing institution: IX Congreso Nacional de la Sociedad Española de Hematología y Oncología Pediátricas

Title: Gene editing of PKLR gene in human hematopoietic progenitors
Speaker: Fañanas Baquero, S., Orman, I., Gouble, A., Galetto, R., Poirot, L., Bueren, J., Quintana-Bustamante, O. and Segovia, J C.
Date: March 2016
Place: Marsella
Organizing institution: French Society for Gene and Cell Therapy Annual Congress

Title: Non targeted and targeted gene therapy approaches in Fanconi Anemia
Speaker: Bueren, J.
Date: March 2016
Place: Barcelona
Organizing institution: REACT

Title: Characterization and transduction with a therapeutic lentiviral vector of hematopoietic progenitors form pyruvate kinase deficient 8PKD) patients
Speaker: Navarro, S., Lopez-Manzaneda, S., Garcia-Gomez, M., Sanchez-Dominguez, R, Garcia-Bravo, M., Alberquilla, O., Mañu, MM., Muriel-Ramos, M., Vives-Corrons, JL., Sevilla, J., Bueren, J. and Segovia, J C.
Date: March 2016
Place: Castelldefels
Organizing institution: IX Reunión Anual CIBERER

Title: Gene Therapy for PKD and other rare disorders
Speaker: Segovia, JC, 
Date: January 2016
Place: Lisboa
Organizing institution: European School of Haematology

Title: CRISPR/Cas9 knock-out of the PKLR gene in human cells and hematopoietic progenitors as a cellular model of Pyruvate Kinase Deficiency
Speaker: Lopez-Manzaneda, S., Torres, R., Garcia-Torralba, A., Ramirez, JC., Bueren, JA. and Segovia, J C.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Gene Editing in induced pluripotent -and adult- stem cells for the Treatment of Hematopoietic Diseases
Speaker: Quintana-Bustamante, O., Lopez-Manzaneda, S., Fañanas, S., Sanchez-Dominguez, R and Segovia, J C.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Targeted Gene Correction of Pyruvate Kinase Deficiency in patient-specific Stem Cells
Speaker: Quintana-Bustamante, O., Garate, Z., Fañanas-Baquero, S., Olivier, E., Crane, AM., Poirot, L., Galetto, R., Kosinski, P., Hill, C., Kung, C., Agirre, X., Orman, I., Cerrato, L., Alberquilla, O., Rodriguez-Fornes, F., Fusaki, N., Garcia-Sanchez, F., Mia, TM., Ribeiro, ML., Sevilla, J., Prosper, F., Jin, S., Mounford, J., Guenechea, G., Gouble, A., Davis, BR., Bueren, J. and Segovia, J C.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Myocardial infarction scar formation: endogenous cell dynamics & the development of cell therapies to treat the diseases heart.
Speaker: Ruiz-Villalba, A., Simon, AM., Pogntke, C., Castillo, MI., Abizanda, G., Pelacho, B., Sanchez-Dominguez, R, Segovia, J C., Prosper, F. and Perez-Pomares, JM.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Moving from the preclinical to the clinical gene therapy of Fanconi anemia.
Speaker: Rio, P, Navarro, S., Guenechea, G., Molina, J., Sanchez, R., Lozano, ML., Casado, JA., Yanez, R., Lamana, M., Galy, A., Segovia, J C., Surralles, J., Diaz de heredia, C. and Bueren, JA.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Lentiviral Vectors Pseudotyped with Measles Virus HF Envelope Proteins Efficiently Target Hematopoietic Progenitor Cells in Unfractionated Bone Marrow from Fanconi Anemia Patients
Speaker: Roman-Rodriguez, F., Levy, C., Bernandin, O., Costa, C., Diez, B., Alvarez, L., Bueren, J., Verhoeyen, E. and Rio, P.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Gene Therapy in Rare Anemias
Speaker: Segovia JC
Date: November 2015
Place: Amsterdam (Holanda)
Organizing institution: 6th European Symposium on Rare Anaemias

Title: Reprogramming human B-cells into induced pluripotent stem cells and its enhancement by C/EBPa
Speaker: Bueno, C., JL., Sardina, Di Stefano, B., Romero-Moya, D., Muñoz-Lopez, A., Ariza, L., Chillon, MC., Balanzategui, A., Castaño, J., Herreros, A., Fraga, MF., Granada, I., Quintana-Bustamante, O., Segovia, J C., Nishimura, K., Ohtaka, M., Nakanishi, M., Graf, T. and Menendez, P.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Mesenchymal stromal cells enhance the engraftment of low numbers of hematopoietic stem cells in a mouse model of autologous transplantation
Speaker: Fernandez-Garcia, M., Yanez, R., Sanchez-Dominguez, R, Peces-Barba, M., Hernando, M., Herrera, G., O'Connor, JE., Segovia, J C., Bueren, JA. and Lamana, M.
Date: November 2015
Place: San Sebastián
Organizing institution: Spanish Society for Gene and Cell Therapy 8th Biennial Congress

Title: Versuche mit Gentherapie be Patienten mit Fanconi-Anamie
Speaker: Rio, P
Date: October 2015
Place: Gersfeld, Alemania
Organizing institution: Familien-, Ärzte- und Wissenschaftlertreffen

Title: Gene Therapy Approaches for Fanconi Anemia using Hematopoietic and Pluripotent Stem Cells
Speaker: Bueren, J.
Date: September 2015
Place: Manchester (Reino Unido)
Organizing institution: EMBO Conference

Title: Lentiviral-mediated correction of mobilized CD34+progenitors and repopulating cells from Fanconi anemia patients
Speaker: Rio, P., Navarro, S., Guenechea, G., Sanchez-Dominguez, R., Lozano, ML., Casado, JA., Yañez, R., Lamana, M., Galy, A., Segovia, J C., Surralles, J., Diaz de Heredia, C., Sevilla, J. and Bueren, J.
Date: September 2015
Place: Helsinki (Finlandia)
Organizing institution: ESGCT Collaborative Congress

Title: Lentiviral-Mediated Gene Correction of Hematopoietic Progenitors and Repopulating Cells from FA-A Patients Using a Validated GMP Transduction Protocol
Speaker: Navarro, S., Rio, P, Guenechea, G., Lozano, ML., Galy, A., Alvarez, L., Cerrato, L., Hernando, M., Lamana, M., Yañez, R., Surralles, J., Diaz de Heredia, C., Sevilla, J. and Bueren, J.
Date: September 2015
Place: Toronto (Canadá)
Organizing institution: 27th Annual Fanconi Anemia Research Fund Scientific Symposium

Title: Mesenchymal stem cells modulate experimental arthritis by inducing an early regulatory adaptive T response
Speaker: Lopez-Santalla, M., Mancheño-Corvo, P., Menta, R., Lopez-Belmonte, J., De la Rosa, O., Dalemans, W., Lombardo, E., Bueren, J. and Garin, M.
Date: September 2015
Place: Viena
Organizing institution: 4th European Congress of Immunology

Title: Efficient non-viral gene delivery by minicircle Sleeping Beauty transposon system into hematopoietic stem cells for gene therapy applications
Speaker: Holstein, M., Mesa-Nuñez, C., Almarza, E., Miskey, C., Schmeer, M., Kobelt, D., Walther, W., Izsvak, Z., Schleef, M., Rudolph, C., Bueren, J., Guenechea, G. and Ivics, Z.
Date: September 2015
Place: Helsinki (Finlandia)
Organizing institution: ESGCT Collaborative Congress

Title: Use of multicolor flow cytometry for the quantification of hematopoietic progenitor cells in Fanconi anemia patients
Speaker: Segovia, JC, Sanchez-Dominguez, R, Alberquilla, O, Rio, P, Navarro, S, Guenechea, G, Casado, JA, Surralles, J, Sevilla, J, Diaz de Heredia, C and Bueren, J.
Date: June 2015
Place: Las Palmas de Gran Canaria (Spain)
Organizing institution: XIV Congress Iberian Cytometry Society

Title: Fanconi anemia: genetic pathways to leukemia
Speaker: Rio, P
Date: June 2015
Place: Viena (Austria)
Organizing institution: 20th Congress European Hematology Association

Title: Gene Therapy of Genetic and Metabolic Diseases
Speaker: Bueren, J.
Date: May 2015
Place: New Orleans (EEUU)
Organizing institution: 20th Congress European Hematology Association

Title: Drug screening to reduce chromosome fragility in Fanconi anemia
Speaker: Ramirez, MJ, Montanuy, H, Minguillón, J, Casado, JA, Bueren, J and Surralles, J.
Date: March 2015
Place: El Escorial (Madrid)
Organizing institution: VII Reunión Anual CIBERER

Title: Minicircles for transposon delivery in hematopoietic stem cells
Speaker: Mesa, C, Leon, D, Sanchez, R, Aldea, M, Bueren, J, Guenechea, G and Almarza, E.
Date: March 2015
Place: El Escorial (Madrid)
Organizing institution: VII Reunión Anual CIBERER

Title: Improving the therapeutical effectiveness of extracorporeal photopheresis by using new photochemotherapeutic compounds
Speaker: Garcia-Bernal, D., Blanquer, M., Alguero, MC., del Río, JA., Correa, E., Yañez, R., Lamana, M. and Moraleda, JM.
Date: March 2015
Place: Estambul (Turquía)
Organizing institution: EBMT 2015

Title: Terapia génica en los síndromes de fallo medular congénito
Speaker: Bueren, J.
Date: November 2014
Place: Madrid (Spain)
Organizing institution: LVI Congreso Nacional de la Sociedad Española de Hematología y Hemoterapia

Title: Ex vivo Gene Therapy in a Mouse Model of Leukocyte Adhesion Dficiency Type I
Speaker: Almarza, E, Leon, D, Aldea, M, Sanchez, R, Thrasher, AJ and Bueren, J.
Date: October 2014
Place:The Hague (Netherlands)
Organizing institution: ESGCT and NVGCT Collaborative Congress

Title: Towards the lentiviral gene therapy of mobilized CD34+ Cells from Fanconi anemia patients
Speaker: Bueren, J.
Date: October 2014
Place:The Hague (Netherlands)
Organizing institution: ESGCT and NVGCT Collaborative Congress

Title: Mesenchymal stromal cells enhance the engraftment of low numbers of hematopoietic stem cells in a mouse model of autologous transplantation
Speaker: Fernandez-Garcia, M, Yañez, R, Sanchez-Dominguez, R, Bueren, J and Lamana, M.
Date: October 2014
Place:The Hague (Netherlands)
Organizing institution: ESGCT and NVGCT Collaborative Congress

Title: Towards TALEN-mediated targeting of FANCA in the AAVS1-homolog safe harbor locus in FA-A mice
Speaker: Pino-Barrio, MJ, Navarro, S, Chinchón, R, Rio, P, Sanchez-Dominguez, R, Mussolino, C, Cathomen, T and Bueren, J.
Date: October 2014
Place: The Hague (Netherlands)
Organizing institution: ESGCT and NVGCT Collaborative Congress

Title: Genetic correction of induced pluripotent stem cells from a Wiskott-Aldrich Syndrome patient normalizes the immune defects
Speaker: Davis, BR., Laskowski, TJ., Van Caeneghem, Y., Pourebrahim, R., Li, XS., Liao, W., Garate, L., Crane, AM., Segovia, J C., Holmes, M. C., Ni, Z., Kaufman, D. and Vandekerckhove, B.
Date: October 2014
Place: The Hague (Netherlands)
Organizing institution: ESGCT and NVGCT Collaborative Congress

Title: Collection of G-CSF and Plerixafor Mobilized CD34+ Cells from FA Patients for Subsequent Use FA Gene Therapy
Speaker: Sevilla, J, Díaz de Heredia, C, Rio, P, Navarro, S, Sanchez, R, Segovia, J C, Casado, J, Madero, L, Sanchez de Toledo, J, Surralles, J. and Bueren, J.
Date: October 2014
Place: Sevilla (Spain)
Organizing institution: VII Congreso Internacional de la Red Española de Investigación en Anemia de Fanconi

Title: Validation of the GMP Transduction Conditions to be Used in a Lentiviral Vector-mediated Gene Therapy Trial on FA-A Patients
Speaker: Navarro, S, Rio, P, Lozano, ML, Lamana, ML, Yáñez, R, Hernando, M, Alvarez, L, Cerrato, L, Casado, J, Surralles, J, Charrier, S, Galy, A, Díaz de Heredia, C, Sevilla, J and Bueren, J.
Date: October 2014
Place: Sevilla (Spain)
Organizing institution: VII Congreso Internacional de la Red Española de Investigación en Anemia de Fanconi

Title: Homologous Recombination-based Gene therapy in Stem Cells from Fanconi Anemia Patients
Speaker: Diez, B, Baños, R, Genovese, P, Alvarez, L, Lombardo, A, Schiroli, G, Quintana-Bustamante, O, Garate, Z, Samper, E, Gregory, PD, Holmes, MC, Naldini, L, Bueren, J and Rio, P.
Date: October 2014
Place: Sevilla (Spain)
Organizing institution: VII Congreso Internacional de la Red Española de Investigación en Anemia de Fanconi

Title: Insertion Site Analyses of Therapeutic Lentiviral Vectors in Hematopoietic Stem Cells from Fanconi Anemia-A Mice
Speaker: Guenechea, G, Molina-Estévez, FJ, Nowrouzi, A, Lozano, ML, Galy, A, Charrier, S, Von Kalle, C, Schmidt, M and Bueren, J.
Date: October 2014
Place: Sevilla (Spain)
Organizing institution: VII Congreso Internacional de la Red Española de Investigación en Anemia de Fanconi

Title: Development of a cellular model of Pyruvate Kinase Deficiency in human progenitors using shRNA lentiviral Vectors
Speaker: Lopez-Manzaneda, S, Gonzalez-Rubio, ML, Garcia-Bravo, M, Bueren, J, Garcia-Gomez, M and Segovia, JC.
Date: September 2014
Place: Primosten, Croacia
Organizing institution: Power of Viral Vectors in Gene Therapy and Basic Science

Title: Development of new lentiviral vectors for the gene therapy of LAD-I
Speaker: Leon, D, Aldea, M, Sanchez, R, Santilli, G, Thrasher, AJ, Bueren, J and Almarza, E.
Date: September 2014
Place: Primosten, Croacia
Organizing institution: Power of Viral Vectors in Gene Therapy and Basic Science

Title: Stable Engraftment and Continuous Turnover of Fanconi Anemia-A Mouse HSCs after Lentiviral Vector-Mediated Gene Therapy
Speaker: Guenechea, G, Molina-Estévez, FJ, Nowrouzi, A, Lozano, ML, Galy, A, Charrier, S, Von Kalle, C, Schmidt, M and Bueren, J.
Date: September 2014
Place: Bethesda (EEUU)
Organizing institution: 26th Annual Fanconi Anemia Research fund Scientific Symposium

Title: Gene Targeting.mediated Approaches for the Generation of Disease Free Fanconi Anemia Hematopoietic Precursor Cells
Speaker: Díez, B, Baños, R, Genovese, P, Alvarez, L, Lombardo, A, Schiroli, G, Quintana-Bustamante, O, Garate, Z, Samper, E, Gregory, PD, Holmes, MC, Naldini, L, Bueren, J and Rio, P.
Date: September 2014
Place: Bethesda (EEUU)
Organizing institution: 26th Annual Fanconi Anemia Research fund Scientific Symposium

Title: Advanced Therapies for the Treatment of Erythroid Metabolic Diseases: the Pyruvate Kinase Deficiency
Speaker: Garcia-Gomez, M, Garate, Z, Navarro, S, Quintana-Bustamante, O, Crane, AM, Olivier, E, Cerrato, L, Martin, MA, Orman, I, Alberquilla, O, Garcia-Bravo, M, Sanchez, R, Aguirre, X, Maia, T, Ribeiro, L, Sevilla, J, Fusaki, N, Garcia, F, Gouble, A, Mounford, J, Prosper, F, Antoniou, M, Bueren, J, Davis, BR and Segovia, JC.
Date: September 2014
Place: Lisboa
Organizing institution: ESCCA

Title: Gene therapy in Fanconi anemia
Speaker: Río P
Date: May 2014
Place: Génove, Italy
Organizing institution: XXXIX Congresso Nazionale AIEOP

Title: Mesenchymal stromal cells enhance hematopoietic engraftment in a mouse model of autologous transplantation with high risk of engraftment failure
Speaker: Fernandez, M
Date: April 2014
Place: Paris, France
Organizing institution: ISCT 2014

Title: Direct subtyping and mutational analysis in Fanconi anemia by whole exome sequencing
Speaker: Bogliolo, M, Pujol, R, Casado, JA, Bueren, J and Surralles, J.
Date: March2014
Place: El Escorial (Madrid)
Organizing institution: VII Reunión Anual CIBERER

Title: Intralymphatic administration of adipose mesenchymal stem cells shows therapeutic effects in experimental colitis and arthritis
Speaker:Escolano, A, Garin, M, Lopez-Santalla, M, Menta, R, De la Rosa, O, Redondo, JM, Dalemans, W and Lombardo, A.
Date: November 2013
Place: Nueva York (EEUU)
Organizing institution: IFATS

Title: Las células estromales mesenquimales mejoran el injerto hematopoyético en un modelo de alto riesgo de fallo de injerto.
Speaker: Lamana, M, Fernandez, M, Yañez, R, Sanchez-Dominguez, R, Busto, P, Segovia, JC and Bueren, J.
Date: November 2013
Place: Murcia (Spain)
Organizing institution: Reunión Anual TerCel

Title: Advanced therapies for the treatment of erythroid metabolic diseases: The pyruvate kinase deficiency.
Speaker: García-Gómez, M, Garate, Z, Navarro, S, Quintana-Bustamante, O, Krane, A, Cerrato, L, Martín, MA, Orman, I, García-Bravo, M, Sánchez-Rodríguez, R, Sevilla, J, Maia, T, Ribeiro, L, Fusaki, N, García-Sanchez, F, Agirre, X, Gouble, A, Prósper, F, Antoniou, M, Bueren, J, Davis, BR and Segovia, J C.
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Rescue of T-cell deficiency in PRKDC SCID mice by transplantation of gene-edited haematopoietic stem cells
Speaker: Rocca, C, Abdul-Razak, HH, Howe, S, Alonso, ME, Gabriel, R, Bartholomae, CC, CH, Victor Gan, Garín, M, Molina-Estévez, FJ, Roberts, A, Blundell, MP, Wang, J, Prakash, V, Guenechea, G, Holmes, MC, Gregory, PD, Kinnon, C, Von Kalle, C, Schmidt, M, Bueren, J, Thrasher, AJ and Yáñez-Muñoz, RJ
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Long-term preclinical studies of a FANCA lentiviral vector in a Fanconi anemia-A mouse model
Speaker: Molina-Estévez, FJ, Nowrouzi, A, Lozano, ML, Galy, A, Charrier, S, Von Kalle, C, Guenechea, G, Bueren, J and Schmidt, M.
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Development of new lentiviral vectors for the gene therapy of LAD-I
Speaker: Leon, D, Aldea, M, Santilli, G, Thrasher, AJ, Bueren, J and Almarza, E.
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Inflammatory effects of galectin-1-deficient regulatory T cells in a T cell transfer model of inflammatory bowel disease.
Speaker: López-Santalla, M, Escribano, O, Bueren, J and Garín, M.
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Gene knock-in using specific TALE nucleases restores erythroid differentiation defect of humaniPSC obtained from pyruvate kinase deficient patients
Speaker: Garate, Z, Quintana-Bustamante, O, Crane, AM, Cerrato, L, Orman, I, Sevilla, J, Maia, T, Ribeiro, L, Fusaki, N, García-Sanchez, F, Agirre, X, Gouble, A, Prósper, F, Bueren, J, Davis, BR and Segovia, JC.
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Mesenchymal stromal cells reduce graft failure in autologous transplantation models with a high risk of poor engraftment
Speaker: Fernández, M, Yáñez, R, Sánchez-Dominguez, R, Busto, P, Segovia, JC, Bueren, J and Lamana, M.
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Towards the gene therapy of Fanconi anemia with lentiviral vectors
Speaker: Bueren, J.
Date: October 2013
Place: Madrid (Spain)
Organizing institution: European Society of Gene and Cell Therapy - Sociedad Española de Terapia Génica y Celular (Collaborative Congress)

Title: Therapeutic effect of adipose mesenchymal stem cells on experimental colitis and arthritis
Speaker: Mancheño-Corvo, P, Escolano, A, Garin, M, Lopez-Santalla, M, Menta, R, De la Rosa, O, Dalemans, W and Lombardo, A.
Date: May 2013
Place: Ghent (Belgium)
Organizing institution: Knowledge for Growth 2013

Title: Novel Gene Therapy Approaches in Fanconi Anemia
Speaker: Bueren, J.
Date: May 2013
Place: Algarve, Portugal
Organizing institution: 8th International Meeting of the Portuguese Society for Stem cells and Cell Therapies

Title: Development of a Phase I/II Gene Therapy Trial in Fanconi Anemia
Speaker: Bueren, J.
Date: February 2013
Place: El Escorial (Madrid)
Organizing institution: VI Reunión anual CIBERER

Title: Application of induced Pluripotent Stem Cells in Hematological Genetic Diseases
Speaker: Segovia, JC.
Date: October 2012
Place: Versailles, France
Organizing institution: European Society of Gene and Cell Therapy

Title: Generation of Disease Fanconi Anemia iPSC-derived Hematopoietic Progenitors with ZFN-mediated targeted addition of FANCA to the AAVS1 locus
Speaker: Rio, P, Baños, R., Lombardo, A., Garate, L., Quintana-Bustamante, O., Alvarez, L., Torres, Y., Genovese, P., Navarro, S., Segovia, J C., Samper, E., Gregory, P.D., Holmes, M. C., Naldini, L. and Bueren, J.
Date: October 2012
Place: Versailles, France
Organizing institution: European Society of Gene and Cell Therapy Collaborative Congress

Title: Generation of Disease-free iPS Cells from Fanconi Anemia Mice with a Hypomorphic Mutation in Brca2
Speaker: Moleiro, V, Navarro, S, Lozano, M, Chinchón, R, Almarza, E, Quintana-Bustamante, O, Rio, P, Mostoslavsky, G, Maetzig, T, Schiedlmeier, B, Modlich, U, Galla, M, Samper, E, Segovia, JC, Raya, A, Guenechea, G, Baum, C, Izpisua-Belmonte, JC and Bueren, J.
Date: October 2012
Place: Versailles, France
Organizing institution: European Society of Gene and Cell Therapy Collaborative Congress

Title: Terapia génica en anemia de Fanconi
Speaker: Bueren, J.
Date: October 2012
Place: Madrid (Spain)
Organizing institution: I Simposio Internacional "Terapia Celular con Células Madre Adultas" De la investigación a la clínica

Title: Discovery of a Novel Fanconi Anemia Gene by Whole Exome Sequencing
Speaker: Bogliolo, M, Schuster, B, Stoepker, C, Derkunt, B, Su, Y, Raams, A, Trujillo, J, Minguillón, J, Ramírez, MJ, Pujol, R, Casado, J, Baños, R, Rio, P, Knies, K, Zuñiga, S, Benítez, J, Bueren, J, Jaspers, NGJ, Scharer, OD, de Winter, JP, Schindler, D and Surralles, J.
Date: September 2012
Place: Denver (EEUU)
Organizing institution: FARF

Title: Generation of Disease-free Fanconi Anemia Hematopoietic Progenitors by Gene Targeting and Cell Reprogramming Approaches
Speaker: Baños, R, Rio, P, Lombardo, A, Quintana-Bustamante, O, Garate, Z, Álvarez, L, Genovese, P, Navarro, S, Segovia, JC, Trujillo, J, Surralles, J, Gregory, PD, Holmes, MC, Naldini, L and Bueren, J.
Date: September 2012
Place: Denver (EEUU)
Organizing institution: FARF

Title: Gene Therapy and Cell Reprogramming in Fanconi Anemia
Speaker: Bueren, J.
Date: September 2012
Place: Génova
Organizing institution: EHA

Title: Gene Therapy Strategies in Fanconi Anemia
Speaker: Bueren, J.
Date: May 2012
Place: Philadelphia (EEUU)
Organizing institution: Gene Therapy Strategies in Fanconi Anemia

Title: Stem Cell Gene Therapy for Fanconi Anemia
Speaker: Rio, P and Bueren, J.
Date: February 2012
Place: Hannover, Germany
Organizing institution: Third International Workshop on Congenital Bone Marrow Failure Syndromes

Title: Gene editing and cell reprogramming of fibroblasts from Fanconi anemia patients: An optimized approach for the generation of blood cells from skin fibroblasts.
Speaker: Paula Río Galdo
Date: January 2012
Place: Leukerbad, Switzerland
Organizing institution: 4th Annual Meeting PERSIST

Title: New gene therapy vectors for the treatment of the primary immunodeficiency LAD-I
Speaker: Diego Leon Rico
Date: January 2012
Place: Leukerbad, Switzerland
Organizing institution: 4th Annual Meeting PERSIST

Title: Development of clinically applicable lentiviral vectors for the treatment of Pyruvate Kinase Deficiency
Speaker: García, M.
Date: January 2012
Place: Leukerbad, Switzerland
Organizing institution: 4th Annual Meeting PERSIST

Title: Generation of Fanconi anemia iPS cells with a targeted integration of FANCA in the AAVS1 locus
Speaker: Baños, R, Rio, P, Lombardo, A, Quintana-Bustamante, O, Garate, Z, Alvarez, L, Genovese, P, Navarro, S, Yáñez, R, Segovia, JC, Gregory, PD, Holmes, MC, Naldini, L and Bueren, J.
Date: October 2011
Place: Brighton, RU
Organizing institution: European Society of Gene and Cell Therapy

Title: Gene Correction of Erythroid Metabolic Diseases: Pyruvate Kinase Deficiency
Speaker: José Carlos Segovia Sanz
Date: October 2011
Place: Barcelona-Workshop on Gene Therapy for Rare Diseases
Organizing institution: CIBERER in collaboration with IDIBAPS y CRG.

Title: Engraftment of Immunodeficient mice with Fanconi Anemia-like Hematopoietic Repopulating Cells: A New Humanized Model of Fanconi Anemia
Speaker: Paula Río Galdo
Date: October 2011
Place: Barcelona
Organizing institution: 23rd Annual Fanconi Anemia Research Fund Scientific Symposium

Title: Generation of Disease-free iPS Cells from hFA-A Fibroblasts with a Targeted Integration of FANCA in the "Safe Harbor" AAVS1 Locus.
Speaker: Juan A. Bueren
Date: October 2011
Place: Barcelona (Spain)
Organizing institution: 23rd Annual Fanconi Anemia Research Fund Scientific Symposium

Title: Generation and Hematopoietic Differentiation of Disease-free Induced Pluripotent Stem Cells from FA-D1 Mouse Fibroblasts
Speaker: Navarro, S, Moleiro, V, Molina-Estévez, FJ, Knöss, S, Chinchón, R, Lozano, M, Almarza, E, Quintana-Bustamante, O, Leon, D, Segovia, JC, Samper, E, Maetzig, T, Galla, M, Guenechea, G, Modlich, U, Baum, C and Bueren, J.
Date: October 2011
Place: Barcelona (Spain)
Organizing institution: 23rd Annual Fanconi Anemia Research Fund Scientific Symposium

Title: Targeted integration of transgenes in a "safe harbor" locus using engineered meganuclease-based homologous recombination strategies.
Speaker: Rodriguez-Fornes, F, Quintana-Bustamante, O, Cerrato, L, Gloube, A, Galetto, R, Pioirot, L, Paques, F, Guenechea, G, Segovia, JC and Bueren, J.
Date: September 2011
Place: Zaragoza (Spain)
Organizing institution: VI Congreso de la Sociedad Española de Terapia Génica y Celular

Title: New approaches for the gene therapy of Fanconi anemia
Speaker: Bueren, J.
Date: September 2011
Place: Zaragoza (Spain)
Organizing institution: VI Congreso de la Sociedad Española de Terapia Génica y Celular

Title: Involvement of the Fanconi anemia pathway in the response of transformed and untransformed cells to DNA-binding anticancer drugs of marine origin
Speaker: Martinez, S, Pérez, L, Baños, R, Rio, P, Segovia, JC, Orman, I, Casado, J, Galmarini, C, Aracil, M, Tercero, JC, Albella, B and Bueren, J.
Date: September 2011
Place: Salamanca (Spain)
Organizing institution: XIII Congreso Nacional ASEICA

Title: New Approaches for the Gene Therapy of Inherited Bone Marrow Failure Syndromes: The Fanconi Anemia Model.
Speaker: Juan A. Bueren
Date: June 2011
Place: Torino (Italy)
Organizing institution: 36th FEBS Congress

Title: Genetically Corrected Blood Cells for Fanconi Anemia
Speaker: Juan A. Bueren
Date: February 2011
Place: Berlin
Organizing institution: Spanish Embassy in Berlin. 4th Berlin Conference on IP in Life Sciences.

Title: Stable Knock-Down of hFANCA for the Development of a Humanized Model of Fanconi Anemia
Speaker: Rio, P.
Date: January 2011
Place: Leukerbad, Switzerland
Organizing institution: PERSIST-7th European frame project

Title: Towards DNA-pk deficicient cell reprogramming
Speaker: Francisco Javier Molina Estévez
Date: January 2011
Place: Leukerbad, Switzerland
Organizing institution: PERSIST-7th European frame project

Title: Stable Knockdown of hFANCA for the Development of a Humanized Model of Fanconi Anemia
Speaker: Paula Río Galdo
Date: January 2011
Place: Leukerbad, Switzerland
Organizing institution: PERSIST-7th European frame project

Title: Generation and Hematopoietic Differentiation of Disease-free Induced Pluripotent Stem Cells in Mouse Models of Fanconi Anemia.
Speaker: Juan A. Bueren
Date: November 2010
Place: Milano
Organizing institution: 18th Meeting of the ESGCT

Title: Ectopic expression of BRCA1 Corrects Fanconi Anemia Pathway and Chromosomal Instability in CML cells
Speaker: Valeri, A, Alonso, ME, Río, P, Pujol, R, Casado, JA, Pérez, L, Jacome, A, Agirre, X, Calasanz, MJ, Hanenberg, H, Surrallés, J, Prósper, F, Albella, B and Bueren, JA.
Date: October 2010
Place: Milan (Italy)
Organizing institution: XVII Annual Congress ESGCT

Title: Generation and hematopoietic differentiation of disease-free iPSCs in mouse models of Fanconi Anemia
Speaker: Navarro, S, Moleiro, V, Chinchón, R, Molina-Estévez, FJ, Lozano, ML, Samper, E, Schiedlmeier, B, Maetzig, T, Galla, M, Schambach, A, Mostoslavsky, G, Segovia, JC, Raya, A, Güenechea, G, Baum, C, Izpisua-Belmonte, JC and Bueren, JA.
Date: October 2010
Place: Milan (Italy)
Organizing institution: XVII Annual Congress ESGCT

Title: The relevance of the FANCONI Anemia/BRCA Pathway in the Chromosomal Instability of Chronic Myeloid Leukemia Cells
Speaker: Valeri, A, Alonso, ME, Río, P, Pujol, R, Casado, JA, Pérez, L, Jacome, A, Agirre, X, Calasanz, MJ, Hanenberg, H, Surrallés, J, Prósper, F, Albella, B and Bueren, JA.
Date: October 2010
Place: Madrid (Spain)
Organizing institution: CIBERER IV Annual Meeting

Title: Traslational research in Fanconi Anemia: improved follow up of cancer risk
Speaker: Belendez, C, Bueren, JA, Surallés, J. 
Date: October 2010
Place: Madrid (Spain)
Organizing institution: CIBERER IV Annual Meeting

Title: New Perspectives for the Gene Therapy of Inherited Hematopoietic Diseases: The Fanconi Anemia Model.
Speaker: Juan A. Bueren
Date: September 2010
Place: Cologne
Organizing institution: Stem Cell Meeting. Miltenyi.

Title: Gene Therapy in Fanconi Anemia. Agosto 2010
Speaker: Juan A. Bueren
Date: August 2010
Place: Reykjavik
Organizing institution: Third Transatlantic Meeting on Gene Therapy.

Title: Fanconi anemia Gene Therapy
Speaker: Juan A. Bueren
Date: July 2010
Place: Berlin
Organizing institution: MDC Berlin

Title: Advanced Therapies in Fanconi Anemia
Speaker: Juan A. Bueren
Date: July 2010
Place: Hannover
Organizing institution: Exp. Hematol. Dpt. Hannover University.

Title: Perspectives for the Gene Therapy of Inherited Hematopoietic Stem Cell Diseases: The Fanconi Anemia Model
Speaker: Juan A. Bueren
Date: July 2010
Place: Madrid (Spain)
Organizing institution: Jornada sobre Reprogramación Celular y Células Madre con Pluripotencia Inducida (Células iPS)

Title: The Relevance of Cell Reprogramming in the Gene Therapy of Fanconi Anemia.
Speaker: Juan A. Bueren
Date: March 2010
Place: Frankfurt
Organizing institution: George Speyer House.

Title: Gene Therapy and Cell Reprogramming strategies in Fanconi Anemia.
Speaker: Juan A. Bueren
Date: March 2010
Place: London
Organizing institution: British Society for Gene Therapy. 7th Annual Conference of the British Society for Gene Therapy.

Title: Towards the Development of Advanced Therapies in Fanconi anemia
Speaker: Juan A. Bueren
Date: March 2010
Place: London
Organizing institution: British Society for Gene Therapy. 7th Annual Conference of the British Society for Gene Therapy.

Title: Gene Therapy and Cell Reprogramming in Fanconi Anemia
Speaker: Juan A. Bueren
Date: February 2010
Place: Rotterdam
Organizing institution: Hematology Dept. Erasmus University.

Title: Gene therapy and Cell Reprogramming in Fanconi anemia.
Speaker: Juan A. Bueren
Date: February 2010
Place: Tel-Aviv (Israel)
Organizing institution: Lentivirus Gene Therapy Workshop.