Miriam Hernando Rodríguez


Unit: Complex disorders

E-mail: Miriam.Hernando@externos.ciemat.es

Phone: +34913460809

Miriam studied Biology at the University of the Basque Country, in Leioa, finishing in 2003. She later participated in the CITIUS program for internships at the GlaxoSmithKline company in Tres Cantos, Madrid. She carried out her doctoral thesis at CIC bioGUNE in Vizcaya, with a grant from the Basque Government, studying the involvement of GTPase Rac1 in signaling and cell death mediated by peptide 1-42 β-Amyloid, finishing it in 2009.

Between 2009 and 2011, she worked at the University of the Basque Country in the Department of Human Genetics of the Faculty of Sciences and in the Department of Oral Medicine of the Faculty of Medicine and Dentistry, both at the Leioa campus, in the Basque Country. Later, she worked in the CNIO Cytogenetics Group.

Since 2013, Miriam has been working at the Advanced Therapy Unit and Hematopoietic Innovative Therapies division of CIEMAT / IIS-FJD, studying the effect of the Mesenchymal stromal cells in the treatment of inflammatory and hematological disorders. In addition, she is the Quality Control Supervisor at the GMP facility CliniStem. During these years, the results obtained in the different projects in which she has participated, have resulted in the publication of 10 scientific articles, a patent and 33 participations in congresses.


ORCID: 0000-0001-7272-4372



1.- David García-Bernal; Mariano García-Arranz; Rosa M Yañez; Rosario Hervás-Salcedo; Alfonso Cortés; María Fernández-García; Miriam Hernando-Rodríguez; Óscar Quintana-Bustamante; Juan Antonio Bueren; Damián García-Olmo; José M Moraleda; José Carlos Segovia; Agustín G Zapata. The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy. Frontiers in Cell and Developmental Biology. 16/03/2021.

2.-Rosario Hervás-Salcedo; María Fernández-García; Miriam Hernando-Rodríguez; Óscar Quintana-Bustamante; José Carlos Segovia; Marcio Álvarez-Silva; Mariano García-Arranz; Pablo Monguez; Victoria Del Pozo; Marta Rodríguez de Alba; Damián García-Olmo; Carmen Ayuso; María Luisa Lamana; Juan Antonio Bueren; Rosa María Yañez. Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10 Stem Cell Research and Therapy. Stem Cell Research & Therapy. 2021 - 12, pp. 124. 02/2021.

3.- Paula Río Galdo; Susana Navarro Ordoñez; Wei Wang; Rebeca Sanchez Dominguez; Roser Pujol; Massimo Bogliolo; Eva Merino; Ning Wu; Rocío Salgado; María L Lamana Luzuriaga; Rosa M Yañez González; Jose A Casado; Yari Gimenez; Francisco J Román Rodríguez; Lara Alvarez; Omaira Alberquilla; Anna Raimbault; Guillermo Guenechea; María Luz Lozano Vinagre; Laura Cerrato Carrasco; Miriam Hernando Rodríguez; Eva Gálvez; Raquel Hladun; Irina Giralt; Jordi Barquinero; Anne Galy; Nagore García de Anoín; Ricardo López; Albert Catalá; Jonathan D Schwartz; Jordi Surrallés; Jean Soulier; Manfred Schmidt; Cristina Díaz de Heredia; Julián Sevilla; Juan A Bueren Roncero. Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia. Nature Medicine. 25 - 9, pp. 1396 - 1401. 09/09/2019.

4.- María Fernández-García; María Luisa Lamana; Miriam Hernando-Rodríguez; Rebeca Sánchez-Domínguez; Juan A Bueren; Rosa Yañez. Improved Hematopoietic Gene Therapy in a Mouse Model of Fanconi Anemia Mediated by Mesenchymal Stromal Cells. Human Gene Therapy. 29 - 3, pp. 327 - 336. 2018. 178cd81bdb8a817a417ec102a7733835 14

5.- J Valencia; B Blanco; Rosa Yañez; M Vazquez; C Herrero Sanchez; Maria Fernández-García; C Rodríguez Serrano; D Pescador; JF Blanco; Miriam Hernando-Rodríguez; F Sánchez-Guijo; Maria Luisa Lamana; JC Segovia; A Vicente; C del Cañizo; AG Zapata. Comparative analysis of the immunomodulatory capacities of human bone marrow- and adipose tissue- derived mesenchymal stromal cells from the same donor. Cytotherapy. 18, pp. 1297 - 1311. 2016.

6.- Alba Maiques-Díaz; Miriam Hernando Rodríguez; A Sánchez-López; Ana Rio-Machin; M Shrestha; JC Mulloy; Juan Cruz Cigudosa; Sara Álvarez. MAPK8-mediated stabilization of SP1 is essential for RUNX1-RUNX1T1- driven leukaemia. British Journal of Haematology. 107 - 2, pp. 807 - 810. 2016. Tipo de producción: Artículo científico Tipo de soporte: Revista

7.- María Fernández-García; Rosa Yañez; Rebeca Sánchez-Domínguez; Miriam Hernando-Rodríguez; Miguel Peces-Barba; G Herrera; JE O’Connor; José Carlos Segovia; Juan A Bueren; Maria Luisa Lamana. Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model.Stem Cell Research & Therapy. 6, pp. 165. 2015.

8.- Lorea Manterola; Miriam Hernando-Rodríguez; Asier Ruiz; Aintzane Apraiz; Onetsine Arrizabalaga; Luciano Vellón; Elena Alberdi; Fabio Cabaliere; Hadriano Magiero Lacerda; S Jimenez; Luis Antonio Parada; Carlos Matute; José Luis Zugaza. 1-42 beta-amyloid peptide requires PDK1/nPKC/Rac1 pathway to induce neuronal death.Translational Psychiatry.3 - e210, 2013.

9.- Miriam Hernando-Rodríguez; Natalia Rey-Barja; Xabier Marichalar-Mendia; María José Rodríguez-Tojo; Amelia Acha-Sagredo; José Manuel Aguirre-Urizar. Role of Cytochrome P-450 genetic polymorphisms in oral carcinogénesis. Journal of Oral Pathology and Medicine. 41 - 1, pp. 1 - 8. 2012.

10.- Xabier Marichalar-Mendia; Amelia Acha-Sagredo; María José Rodríguez-Tojo; Natalia Rey-Barja; Miriam Hernando-Rodríguez; José Ignacio Aguirregaviria; José Manuel Aguirre-Urizar. Alcohol-dehydrogenase (ADH1B) Arg48His Polymorphism in Basque Country Patients with Oral and Laryngeal Cancer: Preliminary Study. Anticancer Research. 31 - 2, pp. 677 - 680. 2011.