Marina Inmaculada Garín Ferreira

Dr. Garin joined the Unit for Advanced Therapies at the CIEMAT/IIS-F Jiménez Díaz since 2006, where she continues with the studies initiated at the Imperial College in London on molecular aspects and functionality of the Treg cells (CITYC project SAF2007-66227) and of a European project within the REGENERAR Consortium. This project was a phase Ib/IIa clinical trial in which patients with refractory rheumatoid arthritis were treated with allogeneic MSCs derived from adipose tissue. Dr Garin also holds projects funded by the Spanish Institute of Health Carlos III (PI17/01161 and PI21/01441) where in vivo studies are been carried out in preclinical models of rheumatoid arthritis and inflammatory bowel disease analysing innate and adaptive immune responses responsible for the modulation of inflammation mediated by the MSCs. At present, is member of the TERAV (RICORS), CIBER-ER networks and TE-MODULO Consortium in Madrid.

Publications:

1. Mercedes Lopez-Santalla; Marina Garín. 2021. Improving the Efficacy of Mesenchymal Stem/Stromal-Based Therapy for Treatment of Inflammatory Bowel Diseases Biomedicines. MDPI AG. 9-11, pp.1507-1552. ISSN 2227-9059. https://doi.org/10.3390/biomedicines9111507.

2. Javier Leceta; Marina I. Garin; Carmen Conde. 2021. Mechanism of Immunoregulatory Properties of Vasoactive Intestinal Peptide in the K/BxN Mice Model of Autoimmune Arthritis.Frontiers in Immunology. 16-12:701862, pp.1-9. https://doi.org/10.3389/fimmu.2021.701862

3. Mercedes Lopez-Santalla; Juan A Bueren; Marina Garín. 2021. Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies EBioMedicine. 69-103427. https://doi.org/10.1016/j.ebiom.2021.103427

4. Raquel Fernandez-Perez; Mercedes Lopez-Santalla; Rebeca Sanchez-Dominguez; Omaira Alberquilla; Irene Gutierrez-Cañas; Yasmina Juarranz; Juan A. Bueren; Marina Garín. 2021. Enhanced Susceptibility of Galectin-1 Deficient Mice to Experimental Colitis Frontiers of Immunology. 12-687443. https://doi.org/10.3389/fimmu.2021.687443

5. Mercedes Lopez-Santalla; Rosario Hervas-Salcedo; Maria Fernandez-Garcia; Juan A Bueren; Marina Garín. 2020. Cell Therapy With Mesenchymal Stem Cells Induces an Innate Immune Memory Response That Attenuates Experimental Colitis in the Long Term.Journal of Crohn´s and Colitis. 14-10, pp.1424-1435. https://doi.org/10.1093/ecco-jcc/jjaa079

6. Carmen Yuste-Calvo; Mercedes Lopez-Santalla; Marina I. Garin; Fernando Ponz. 2020. Theranostic Viral Nanoparticles for Autoimmune Diseases.Journal of Immunobiology. 5-1, pp.149-151. https://doi.org/10.37421/JIB.2020.5.149

7. Mercedes Lopez-Santalla; Raquel Fernandez-Perez; Marina I. Garín. 2020. Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications.Cells. 9-8, pp.1852-1873. https://doi.org/10.3390/cells9081852

8. Yuste-Calvo C; López-Santalla M; Zurita L; Cruz-Fernández CF; Sánchez F; Garín MI; Ponz F. 2019. Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection.Nanomaterials. 9-5, pp.25-30. https://doi.org/10.3390/nano9101438

9. Ricardo Villares; Gabriel Criado; Yasmina Juarranz; et al. 2018. Inhibitory Role of Growth Hormone in
the Induction and Progression Phases of Collagen-Induced Arthritis.Front Immunol. 25-9, pp.1165-1169. https://doi.org/10.3389/fimmu.2018.011652

10. HH Abdul-Razak; CJ Rocca; SJ Howe; et al. 2018. Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency.Sci Rep. 29-8, pp.8214-8227. https://doi.org/10.1038/s41598-018-26439-9

11.Lopez-Santalla, Mercedes; Mancheno-Corvo, Pablo; Escolano, Amelia; et al; Garin, Marina I. 2018. Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis Int J Mol Sci.19-7, pp.1853-1870. ISSN 1422-0067. WOS (1) https://doi.org/10.3390/ijms19071853

12. Martínez, VG; Rubio, C; Martínez-Fernández, M; et al; Garin, MI; Dueñas, M. 2017. BMP4 induces M2 macrophage polarization and favors tumor progression in bladder cancer.Clinical Cancer
Research. 23-23, pp.7388-7399. https://doi.org/10.1158/1078-0432.CCR-17-1004

13 López-Santalla M; Mancheño-Corvo P; Escolano A; et al; Garin MI. 2017. Biodistribution and efficacy of human adipose-derived mesenchymal stem cells following intranodal administration in experimental colitis.Frontiers in Immunology. Jun 8-8, pp.638. https://doi.org/10.3389/fimmu.2017.00638

14 Artículo científico. Mancheño-Corvo P; Lopez-Santalla M; Menta R; et al; Lombardo E. 2017. Intralymphatic administration of adipose mesenchymal stem cells reduces the severity of collagen-induced experimental arthritis.Frontiers in Immunology. April 21-8, pp.462. https://doi.org/10.3389/fimmu.2017.00462