Publicaciones

Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3
Ruiz-Gabarre D, Vallés-Saiz L, Carnero-Espejo A, Ferrer I, Hernández F, Garcia-Escudero R, Ávila J, García-Escudero V.
eBioMedicine, Volume 100, 2024, 104953,
https://doi.org/10.1016/j.ebiom.2023.104953

Modulation of tumor microenvironment by targeting histone acetylation in bladder cancer.
Nunes SP, Morales L, Rubio C, Munera-Maravilla E, Lodewijk I, Suárez-Cabrera C, Martínez VG, Pérez-Escavy M, Pérez-Crespo M, Alonso Sánchez M, Montesinos E, San José-Enériz E, Agirre X, Prósper F, Pineda-Lucena A, Henrique R, Dueñas M, Correia MP, Jerónimo C, Paramio JM.
Cell Death Discov. 2024 Jan 4;10(1):1.
doi: 10.1038/s41420-023-01786-3.
PMID: 38172127

Predictors of response after Bacillus Calmette-Guérin treatment in non muscle invasive bladder cancer.
Rodríguez-Izquierdo M, Del Cañizo CG, Rubio C, Reina IA, Hernández Arroyo M, Rodríguez Antolín A, Dueñas Porto M, Guerrero-Ramos F.
Cancers (Basel). 2023 Nov 23;15(23):5554.
doi: 10.3390/cancers15235554.
PMID: 38067259
PMCID: PMC10705209.

Novel Mouse Cell Lines and In Vivo Models for Human High-Grade Neuroendocrine Lung Carcinoma, Small Cell Lung Carcinoma (SCLC), and Large Cell Neuroendocrine Carcinoma (LCNEC).
Recuero E, Lázaro S, Lorz C, Enguita AB, Garcia-Escudero R, Santos M.
Int. J. Mol. Sci. 2023, 24, 15284.
https://doi.org/10.3390/ijms242015284

CD44v6, STn & O-GD2: promising tumor associated antigens paving the way for new targeted cancer therapies.
Lodewijk I, Dueñas M, Paramio JM, Rubio C.
Front Immunol. 2023 Oct 3;14:1272681.
doi: 10.3389/fimmu.2023.1272681. eCollection 2023.
PMID: 37854601

Anti-EGFR conjugated nanoparticles to deliver Alpelisib as targeted therapy for head and neck cancer.
Juan A, Segrelles C, del Campo-Balguerías A, Bravo I, Silva I, Peral J, Ocaña A, Clemente-Casares P, Alonso-Moreno C, Lorz C.
Cancer Nano 14, 29 (2023).
https://doi.org/10.1186/s12645-023-00180-z

PARP inhibition promotes endothelial-like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry.
Fernández-Cortés M, Delgado-Bellido D, Bermúdez-Jiménez E, Paramio JM, O'Valle F, Vinckier S, Carmeliet P, Garcia-Diaz A, Oliver FJ.
J Pathol. 2023 Mar;259(3):318-330.
doi: 10.1002/path.6043. Epub 2023 Jan 4.
PMID: 36484652

Improved efficacy of mesenchymal stromal cells stably expressing CXCR4 and IL-10 in a xenogeneic graft versus host disease mouse model.
Hervás-Salcedo R, Fernández-García M, Hernando-Rodríguez M, Suárez-Cabrera C, Bueren JA, Yáñez RM.
Front Immunol. 2023 Feb 1;14:1062086.
doi: 10.3389/fimmu.2023.1062086. eCollection 2023.
PMID: 36817457

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resource.
Nguyen, H.T., Tang, W., Webster, A.L.H., Whiteaker, J.R., Chandler, C.M., Errazquin, R., Roohollahi, K., Fritzke, M., Hoskins, E.E., Jonlin, E., Wakefield, L., Sullivan, L.B., Chen, E.Y., Dorsman, J., Brakenhoff, R., Paulovich, A.G., Grompe, M., Garcia-Escudero, R., Wells, S.I., Smogorzewska, A. and Monnat, R.J., Jr (2023),
Int. J. Cancer. Accepted Author Manuscript.
https://doi.org/10.1002/ijc.34506

Early Diagnosis of Oral Cancer and Lesions in Fanconi Anemia Patients: A Prospective and Longitudinal Study Using Saliva and Plasma.
Errazquin R, Carrasco E, Del Marro S, Suñol A, Peral J, Ortiz J, Rubio JC, Segrelles C, Dueñas M, Garrido-Aranda A, Alvarez M, Belendez C, Balmaña J, Garcia-Escudero R.
Cancers. 2023; 15(6):1871.
https://doi.org/10.3390/cancers15061871

Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia.
Errazquin R, Page A, Suñol A, Segrelles C, Carrasco E, Peral J, Garrido-Aranda A, Del Marro S, Ortiz J, Lorz C, Minguillon J, Surralles J, Belendez C, Alvarez M, Balmaña J, Bravo A, Ramirez A, Garcia-Escudero R.
Oral Oncol. 2022 Sep 30;134:106184.
doi: 10.1016/j.oraloncology.2022.106184.
Epub ahead of print. PMID: 36191479.

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications.
Earl J, Calabuig-Fariñas S, Sarasquete ME, Muinelo Romay L, Lopez-Tarruella S, Bellosillo Paricio B, Rodríguez M, Valencia Leoz K, Dueñas Porto M, Tarazona N, Hernandez Losa J, Almeida-Toledo R.
J Vis Exp. 2022 Sep 16;(187).
doi: 10.3791/64123.
PMID: 36190291.

BlaDimiR: A Urine-based miRNA Score for Accurate Bladder Cancer Diagnosis and Follow-up
Suarez-Cabrera C, Estudillo L, Ramón-Gil E, Martínez-Fernández M, Peral J, Rubio C, Lodewijk I, Martín de Bernardo A, García-Escudero R, Villacampa F, Duarte J, de la Rosa F, Castellano D, Guerrero-Ramos F, Real FX, Malats N, Paramio JM, Dueñas M.
European Urology. Published: September 06, 2022
DOI:https://doi.org/10.1016/j.eururo.2022.08.011

Antitumor applications of polyphenol-conjugated turnip mosaic virus-derived nanoparticles.
Velázquez-Lam E, Tome-Amat J, Segrelles C, Yuste-Calvo C, Asensio S, Peral J, Ponz F, Lorz C.
Nanomedicine (Lond). 2022 Aug 25.
doi: 10.2217/nnm-2022-0067. Online ahead of print.
PMID: 36004616

Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma.
Lázaro S, Lorz C, Enguita AB, Seller I, Paramio JM, Santos M.
Cancers (Basel). 2022 Jul 28;14(15):3671.
doi: 10.3390/cancers14153671.
PMID: 35954335

Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration.
Ramírez-Pardo I, Villarejo-Zori B, Jiménez-Loygorri JI, Sierra-Filardi E, Alonso-Gil S, Mariño G, de la Villa P, Fitze PS, Fuentes JM, García-Escudero R, Ferrington DA, Gomez-Sintes R, Boya P.
Autophagy. 2022 Jul 24:1-21. doi: 10.1080/15548627.2022.2103307. Epub ahead of print. PMID: 35875981.

Colorectal Cancer Stem Cells Fuse with Monocytes to Form Tumour Hybrid Cells with the Ability to Migrate and Evade the Immune System.
Montalbán-Hernández K, Cantero-Cid R, Casalvilla-Dueñas JC, Avendaño-Ortiz J, Marín E, Lozano-Rodríguez R, Terrón-Arcos V, Vicario-Bravo M, Marcano C, Saavedra-Ambrosy J, Prado-Montero J, Valentín J, Pérez de Diego R, Córdoba L, Pulido E, Del Fresno C, Dueñas M, López-Collazo E.
Cancers (Basel). 2022 Jul 15;14(14):3445.
doi: 10.3390/cancers14143445.
PMID: 35884505

Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer.
Duréndez-Sáez E, Calabuig-Fariñas S, Torres-Martínez S, Moreno-Manuel A, Herreros-Pomares A, Escorihuela E, Mosqueda M, Gallach S, Guijarro R, Serna E, Suárez-Cabrera C, Paramio JM, Blasco A, Camps C, Jantus-Lewintre E.
Cancers (Basel). 2022 Jun 30;14(13):3216.
doi: 10.3390/cancers14133216.
PMID: 35804987

Hippo-YAP signaling activation and cross talk with PI3K in oral cancer: A retrospective cohort study.
Rodrigo JP, Rodríguez-Santamarta T, Corte D, García-de-la-Fuente V, Rodríguez-Torres N, Lequerica-Fernández P, Lorz C, García-Pedrero JM, de Vicente JC.
Oral Dis. 2022 Aug 11. On line ahead of print.
doi: 10.1111/odi.14350.
PMID: 35951471

Efficient and Fast Generation of Relevant Disease Mouse Models by In Vitro and In Vivo Gene Editing of Zygotes.
Sanchez-Baltasar R, Garcia-Torralba A, Nieto-Romero V, Page A, Molinos-Vicente A, López-Manzaneda S, Ojeda-Pérez I, Ramirez A, Navarro M, Segovia JC, and García-Bravo M.
The CRISPR Journal.Jun 2022.422-434.
http://doi.org/10.1089/crispr.2022.0013
PMID: 35686982

G9a inhibition by CM-272: Developing a novel anti-tumoral strategy for castration-resistant prostate cancer using 2D and 3D in vitro models.
Moreira-Silva F, Outeiro-Pinho G, Lobo J, Guimarães R, Gaspar VM, Mano JF, Agirre X, Pineda-Lucena A, Prosper F, Paramio JM, Henrique R, Correia MP, Jerónimo C.
Biomed Pharmacother. 2022 Jun;150:113031.
doi: 10.1016/j.biopha.2022.113031. Epub 2022 Apr 25.
PMID: 35483199

Genomic landscape and immune-related gene expression profiling of epithelial ovarian cancer after neoadjuvant chemotherapy.
Lodewijk I, Bernardini A, Suárez-Cabrera C, Bernal E, Sánchez R, Garcia JL, Rojas K, Morales L, Wang S, Han X, Dueñas M, Paramio JM, Manso L.
NPJ Precis Oncol. 2022 Jan 27;6(1):7.
doi: 10.1038/s41698-021-00247-3.
PMID: 35087175.

IKKα Induces Epithelial–Mesenchymal Changes in Mouse Skin Carcinoma Cells That Can Be Partially Reversed by Apigenin.
García-García VA, Alameda JP, Page A, Mérida-García A, Navarro M, Tejero A, Paramio JM, García-Fernández RA, Casanova ML.  
International Journal of Molecular Sciences. 2022; 23(3):1375.
https://doi.org/10.3390/ijms23031375

Genomic Landscape of Vinflunine Response in Metastatic Urothelial Cancer.
Bernardini A, Dueñas M, Martín-Soberon MC, Rubio C, Suarez-Cabrera C, Ruiz-Palomares R, Munera-Maravilla E, Lázaro S, Lodewijk I, Rueda D, Gómez-Sánchez D, Alonso-Gordoa T, Puente J, Pinto Á, González-Peramato P, Aguado C, Herrera M, López F, Martinez VMG, Morales L, Castellano D, Paramio JM, de Velasco G.
Cancers. 2022; 14(2):378.
PMID: 35053540
https://doi.org/10.3390/cancers14020378

Toward Tumor Fight and Tumor Microenvironment Remodeling: PBA Induces Cell Cycle Arrest and Reduces Tumor Hybrid Cells’ Pluripotency in Bladder Cancer.
Rubio C, Avendaño-Ortiz J, Ruiz-Palomares R, Karaivanova V, Alberquilla O, Sánchez-Domínguez R, Casalvilla-Dueñas JC, Montalbán-Hernández K, Lodewijk I, Rodríguez-Izquierdo M, Munera-Maravilla E, Nunes SP, Suárez-Cabrera C, Pérez-Crespo M, Martínez VG, Morales L, Pérez-Escavy M, Alonso-Sánchez M, Lozano-Rodríguez R, Cueto FJ, Aguirre LA, Guerrero-Ramos F, Paramio JM, López-Collazo E, Dueñas M.  
Cancers. 2022; 14(2):287.
PMID: 35053451
https://doi.org/10.3390/cancers14020287

ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
Suarez-Cabrera C, Ojeda-Perez I, Sanchez-Baltasar R, Page A, Bravo A, Navarro M, Ramirez A
Cancers 2021, 13, 5588.
https://doi.org/10.3390/cancers13215588         PMID: 34771750

Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models
García-García, V.A.; Alameda, J.P.; Page, A.; Casanova, M.L.
Cells 2021, 10, 1906. https://doi.org/10.3390/cells10081906

CYLD Inhibits the Development of Skin Squamous Cell Tumors in Immunocompetent Mice.
Alameda JP, García-García VA, López S, Hernando A, Page A, Navarro M, Moreno-Maldonado R, Paramio JM, Ramírez Á, García-Fernández RA, Casanova ML.
International Journal of Molecular Sciences. 2021; 22(13):6736. https://doi.org/10.3390/ijms22136736         PMID: 34201751

Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis.
Baltanás FC, Mucientes-Valdivieso C, Lorenzo-Martín LF, Fernández-Parejo N, García-Navas R, Segrelles C, Calzada N, Fuentes-Mateos R, Paramio JM, Bustelo XR, Santos E.
Cancers (Basel). 2021 Apr 29;13(9):2152. doi: 10.3390/cancers13092152.
PMID: 33946974

A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer’s disease. García-Escudero V, Ruiz-Gabarre D, Gargini R, Pérez M, García E, Cuadros R, Hernández IH, Cabrera JR, García-Escudero R, Lucas JJ, Hernández F, Ávila J.
Acta Neuropathol (2021). https://doi.org/10.1007/s00401-021-02317-z
PMID: 33934221

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulates the Cellular Phenotypes of Fanconi Anemia.
Errazquin R, Sieiro E, Moreno P, Ramirez MJ, Lorz C, Peral J, Ortiz J, Casado JA, Roman-Rodriguez FJ, Hanenberg H, Río P, Surralles J, Segrelles C, Garcia-Escudero R.
Genes. 2021; 12(4):548. https://doi.org/10.3390/genes12040548

Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors.
Elorza A, Márquez Y, Cabrera JR, Sánchez-Trincado JL, Santos-Galindo M, Hernández IH, Picó S, Díaz-Hernández JI, García-Escudero R, Irimia M, Lucas JJ.
Brain. 2021 Mar 16:awab087. doi: 10.1093/brain/awab087.
PMID: 33725094

Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy
Lodewijk I, Nunes SP, Henrique R, Jerónimo C, Dueñas M, Paramio JM
Clinical Epigenetics volume 13, Article number: 63 (2021)
DOI: 10.1186/s13148-021-01046-0
PMID: 33802203

Cell Therapies in Bladder Cancer Management
Morales L, Paramio JM
Int J Mol Sci. 2021 Mar 10;22(6):2818.
DOI: 10.3390/ijms22062818
PMID: 33802203

XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence.
Innes AJ, Sun B, Wagner V, Brookes S, McHugh D, Pombo J, Porreca RM, Dharmalingam G, Vernia S, Zuber J, Vannier JB, García-Escudero R, Gil J.
Genes Dev. 2021 Mar 1;35(5-6):379-391. doi: 10.1101/gad.343269.120. Epub 2021 Feb 18.
PMID: 33602872

Neuroendocrine Lung Cancer Mouse Models: An Overview
Lorz C, Oteo M, Santos M.
Cancers 2021, 13, 14
PMID: 33375066
doi.org/10.3390/cancers13010014

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis
Guccini I, Revandkar A, D'Ambrosio M, Colucci M, Pasquini E, Mosole S, Troiani M, Brina D, Sheibani-Tezerji R, Elia AR, Rinaldi A, Pernigoni N, Rüschoff JH, Dettwiler S, De Marzo AM, Antonarakis ES, Borrelli C, Moor AE, Garcia-Escudero R, Alajati A, Attanasio G, Losa M, Moch H, Wild P, Egger G, Alimonti A
Cancer Cell 2020 Oct 26;S1535-6108(20)30543-2. DOI: 10.1016/j.ccell.2020.10.012
PMID: 33186519

Overactivation of the NF-κB pathway impairs molar enamel formation.
Yamada A, Kawasaki M, Miake Y, Yamada Y, Blackburn J, Kawasaki K, Trakanant S, Nagai T, Nihara J, Kudo T, Meguro F, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez Á, Sharpe PT, Maeda T, Takagi R, Ohazama A.
Oral Dis. 2020 Oct; 26(7): 1513-1522
DOI: 10.1111/odi.13384
PMID: 32369672

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Lorenzo-Martín LF, Fernández-Parejo N, Menacho-Márquez M, Rodríguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, García-Pedrero JM, Abad A, García-Macías MC, González N, Lorenzano-Menna P, Pavón MA, González-Sarmiento R, Segrelles C, Paramio JM, Tubío JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR.
Nat Commun. 2020 Sep 22;11(1):4788. doi: 10.1038/s41467-020-18524-3.
PMID: 32963234 PMCID: PMC7508832

Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies
Carvalho S, Abreu CM, Ferreira D, Lima L, Ferreira JA, Santos LL, Ribeiro R, Grenha V, Martínez-Fernández M, Dueñas M, Suárez-Cabrera C, Paramio  JM, Diéguez L, Freitas PP, Oliveira MI.
Front Oncol. 2020 Sep 16;10:1774.doi: 10.3389/fonc.2020.01774. eCollection 2020.
PMID: 33042825 PMCID: PMC7526084 DOI: 10.3389/fonc.2020.01774

DNA Methylation as a Therapeutic Target for Bladder Cancer
Nunes SP, Henrique R, Jerónimo C, Paramio JM
Cells 2020 Aug 7;9(8):1850. doi: 10.3390/cells9081850.
PMID: 32784599 PMCID: PMC7463638

Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism
Hernández IH, Cabrera JR, Santos-Galindo M, Sánchez-Martín M, Domínguez V, García-Escudero R, Pérez-Álvarez MJ, Pintado B, Lucas JJ.
Brain. 2020 Jul 1;143(7):2207-2219. doi: 10.1093/brain/awaa150.
PMID: 32533168 PMCID: PMC7363496

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.
Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez-Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A.
J Exp Med. 2020 Jun 1;217(6). pii: e20191787. doi: 10.1084/jem.20191787.
PMID:32219437

The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas
Gargini R, Segura-Collar B, Herránz B, García-Escudero V, Romero-Bravo A, Núñez FJ, García-Pérez D, Gutiérrez-Guamán J, Ayuso-Sacido A, Seoane J, Pérez-Núñez A, Sepúlveda-Sánchez JM, Hernández-Laín A, Castro MG, García-Escudero R, Ávila J, Sánchez-Gómez P.
Science Translational Medicine  22 Jan 2020:
Vol. 12, Issue 527, eaax1501
DOI: 10.1126/scitranslmed.aax1501

A Novel Prostate Cell Type-Specific Gene Signature to Interrogate Prostate Tumor Differentiation Status and Monitor Therapeutic Response (Running Title: Phenotypic Classification of Prostate Tumors).
Mapelli SN, Albino D, Mello-Grand M, Shinde D, Scimeca M, Bonfiglio R, Bonanno E, Chiorino G, Garcia-Escudero R, Catapano CV, Carbone GM.
Cancers (Basel). 2020 Jan 10;12(1). pii: E176. doi: 10.3390/cancers12010176.
PMID: 31936761

New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma
Santos M.
Mol Cell Oncol. 2020 Jan 7;7(2):1702413. doi: 10.1080/23723556.2019.1702413.
PMID: 32158917; PMCID: PMC7051149.

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice
Page A, Bravo A, Suarez-Cabrera C, Sanchez-Baltasar R, Oteo M, Morcillo MA, Casanova ML,  Segovia JC, Navarro M & Ramirez A.
International Journal of Oral Science volume 12, Article number: 1 (2020) Published: 02 January 2020 DOI: 10.1038/s41368-019-0067-9
PMID: 31900382

G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas.
Palacios-García J, Sanz-Flores M, Asensio A, Alvarado R, Rojo-Berciano S, Stamatakis K, Paramio JM, Cano A, Nieto MÁ, García-Escudero R, Mayor F Jr, Ribas C.
Int J Cancer. 2019 Dec 18. doi: 10.1002/ijc.32838. [Epub ahead of print]
PMID: 31850518

The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells.
López-Mateo I, Alonso-Merino E, Suárez-Cabrera C, Park JW, Cheng SY, Alemany S, Paramio JM, Aranda A.
Thyroid. 2019 Nov 23. doi: 10.1089/thy.2019.0175. [Epub ahead of print]
PMID: 31760908 

Epigenetics of Bladder Cancer: Where Biomarkers and Therapeutic Targets Meet
Martinez VG, Munera-Maravilla E, Bernardini A, Rubio C, Suarez-Cabrera C, Segovia C, Lodewijk I, Dueñas M, Martínez-Fernández M and Paramio JM
Front. Genet., 18 November 2019 | https://doi.org/10.3389/fgene.2019.01125

Prostaglandin F2α-induced Prostate Transmembrane Protein, Androgen Induced 1 mediates ovarian cancer progression increasing epithelial plasticity.
Jiménez-Segovia A, Mota A, Rojo-Sebastián A, Barrocal B, Rynne-Vidal A, García-Bermejo ML, Gómez-Bris R, Hawinkels LJAC, Sandoval P, Garcia-Escudero R, López-Cabrera M, Moreno-Bueno G, Fresno M, Stamatakis K.
Neoplasia. 2019 Nov 14;21(11):1073-1084. doi: 10.1016/j.neo.2019.10.001. [Epub ahead of print]
PMID: 31734628

Differential development of large cell neuroendocrine or small cell lung carcinoma upon inactivation of four tumor suppressor genes.
Lázaro S, Pérez Crespo M,  Lorz C,  Bernardini A, Oteo M,  Enguita AB,  Romero E, Hernández P, Tomás L, Morcillo MA, Paramio JM, Santos M.
Proceedings of the National Academy of Scienes, USA. 2019 Oct 14. pii: 201821745. doi: 10.1073/pnas.1821745116. [Epub ahead of print]
PMID: 31611390

Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status.
Dueñas M, Pérez-Figueroa A, Oliveira C, Suárez-Cabrera C, Sousa A, Oliveira P, Villacampa F, Paramio JM, Martínez-Fernández M.
Sci Rep. 2019 Jul 17;9(1):10362. doi: 10.1038/s41598-019-46652-4.
PMID: 31316092

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression
Segovia C, San José-Enériz E, Munera-Maravilla E, Martínez-Fernández M, Garate L, Miranda E, Vilas-Zornoza A, Lodewijk I, Rubio C, Segrelles C, Vitores Valcárcel L, Rabal O, Casares N, Bernardini A, Suarez-Cabrera C, López-Calderón FF, Fortes P, Casado JA, Dueñas M, Villacampa F, Lasarte JJ, Guerrero-Ramos F, de Velasco G, Oyarzabal J, Castellano D, Agirre X, Prósper F, Paramio JM
Nature Medicine (2019). Published: 03 July 2019
DOI:  https://doi.org/10.1038/s41591-019-0499-y

Comprehensive Molecular Characterization of Squamous Cell Carcinomas.
Lorz C, Segrelles C, Errazquin R, Garcia-Escudero R.
June 7th 2019 [Online First], IntechOpen, DOI: 10.5772/intechopen.85988.

Integrative Metabolomic and Transcriptomic Analysis for the Study of Bladder Cancer.
Loras A, Suárez-Cabrera C, Martínez-Bisbal MC, Quintás G, Paramio JM, Martínez-Máñez R, Gil S, Ruiz-Cerdá JL.
Cancers (Basel). 2019 May 16;11(5). pii: E686. doi: 10.3390/cancers11050686.
PMID: 31100982

Competitive Repopulation Assay of Long-Term Epidermal Stem Cell Regeneration Potential.
Segrelles C, Santos-de-Frutos K, Paramio JM, Lorz C.
Methods Mol Biol. 2019 May 14. doi: 10.1007/7651_2019_234. [Epub ahead of print]
PMID: 31087286

Frequent Alteration of Annexin A9 and A10 in HPV-Negative Head and Neck Squamous Cell Carcinomas: Correlation with the Histopathological Differentiation Grade.
Salom C, Álvarez-Teijeiro S, Fernández MP, Morgan RO, Allonca E, Vallina A, Lorz C, de Villalaín L, Fernández-García MS, Rodrigo JP, García-Pedrero JM.
J Clin Med. 2019 Feb 10;8(2). pii: E229. doi: 10.3390/jcm8020229.
PMID: 30744186

IKKα promotes the progression and metastasis of non-small cell lung cancer independently of its subcellular localization.
Page A, Ortega A, Alameda JP, Navarro M, Paramio JM, Saiz-Pardo M, Almeida EI, Hernández P, Fernández-Aceñero MJ, García-Fernández RA, Casanova ML (2019). Computational and Structural Biotechnology Journal 2019-02 [Epub ahead of print]
DOI: 10.1016/j.csbj.2019.02.003

Premature aging and cancer development in transgenic mice lacking functional CYLD.
Alameda JP, Ramírez Á, García-Fernández RA, Navarro M, Page A, Segovia JC, Sanchez R, Suárez-Cabrera C, Paramio JM, Bravo A, Fernández-Aceñero MJ, Casanova ML.
Aging (Albany NY). 2019 Jan 10. doi: 10.18632/aging.101732. [Epub ahead of print]
PMID: 30631004

Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer.
Segovia C, Martínez-Fernández M, Dueñas M, Rubio C, López-Calderón FF, Costa C, Saiz-Ladera C, Fernández-Grajera M, Duarte J, García Muñoz H, de la Rosa F, Villacampa F, Castellano D, Paramio JM.
Oncotarget. 2017 Jan 2. doi: 10.18632/oncotarget.14453. [Epub ahead of print]
PMID: 28060766

Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

Lázaro S, Pérez-Crespo M, Enguita AB, Hernández P, Martínez-Palacio J, Oteo M, Sage J, Paramio JM, Santos M.
Oncotarget. 2016 Dec 10. doi: 10.18632/oncotarget.13875.
PMID: 27966456

MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression.
Dallavalle C, Albino D, Civenni G, Merulla J, Ostano P, Mello-Grand M, Rossi S, Losa M, D'Ambrosio G, Sessa F, Thalmann GN, Garcia-Escudero R, Zitella A, Chiorino G, Catapano CV, Carbone GM.
J Clin Invest. 2016 Dec 1;126(12):4585-4602. doi: 10.1172/JCI86505.
PMID: 27820701

IKKalpha regulates the stratification and differentiation of the epidermis: implications for skin cancer development.
Alameda JP, Navarro M, Ramírez A, Page A, Suárez-Cabrera C, Moreno-Maldonado R, Paramio JM, Fariña MC, Del Río M, Bravo A, Fernández-Aceñero MJ, Casanova ML.
Oncotarget. 2016 Nov 22;7(47):76779-76792. doi: 10.18632/oncotarget.12527.
PMID: 27732959

WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth.
Gargini R, Escoll M, García E, García-Escudero R, Wandosell F, Antón IM.
Cell Rep. 2016 Nov 15;17(8):1962-1977. doi: 10.1016/j.celrep.2016.10.064.
PMID:27851961

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development
Costa C, Santos M, Martínez-Fernández M, Lorz C, Lázaro S, Paramio JM.
Oncotarget. 2016 Nov 15;7(46):75712-75728. doi: 10.18632/oncotarget.12362.
PMID: 27708231

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.
Tordella L, Khan S, Hohmeyer A, Banito A, Klotz S, Raguz S, Martin N, Dhamarlingam G, Carroll T, González Meljem JM, Deswal S, Martínez-Barbera JP, García-Escudero R, Zuber J, Zender L, Gil J.
Genes Dev. 2016 Oct 1;30(19):2187-2198.
PMID: 27737960

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.
Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.
J Exp Med. 2016 Sep 19;213(10):2167-85. doi: 10.1084/jem.20150282.
PMID: 27621420

Deciphering the role of nuclear and cytoplasmic IKKalpha in skin cancer.
Alameda JP, Gaspar M, Ramírez A, Navarro M, Page A, Suárez-Cabrera C, Fernández MG, Mérida JR, Paramio JM, García-Fernández RA, Fernández-Aceñero MJ, Casanova ML.
Oncotarget. 2016 May 17;7(20):29531-47. doi: 10.18632/oncotarget.8792.
PMID: 27121058

Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53
Page A, Navarro M, Suarez-Cabrera C, Alameda JP, Casanova ML, Paramio JM, Bravo A, Ramirez A.
Oncotarget. 2016 Apr 12;7(15):20902-18. doi: 10.18632/oncotarget.7897.
PMID: 26959115

RNA Detection in Urine: From RNA Extraction to Good Normalizer Molecules.
Martínez-Fernández M, Paramio JM, Dueñas M.
The Journal of molecular diagnostics : JMD J Mol Diagn. 2016 Jan;18(1):15-22. doi: 10.1016/j.jmoldx.2015.07.008. Epub 2015 Nov 14. PMID: 26586227

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases.
SIB Swiss Institute of Bioinformatics Members.
Nucleic Acids Res. 2016 Jan 4;44(D1):D27-37. doi: 10.1093/nar/gkv1310.
PMID: 26615188

EZH2 in Bladder Cancer, a Promising Therapeutic Target.
Martínez-Fernández M, Rubio C, Segovia C, López-Calderón FF, Dueñas M, Paramio JM.
Int J Mol Sci. 2015 Nov 13;16(11):27107-27132. Review.
PMID: 26580594

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer.
Martínez-Fernández M, Dueñas M, Feber A, Segovia C, García-Escudero R, Rubio C, López-Calderón FF, Díaz-García C, Villacampa F, Duarte J, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM.
Oncotarget. 2015 Oct 17. doi: 10.18632/oncotarget.5546. [Epub ahead of print]
PMID: 26517683

Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer.
Martínez-Fernández M, Feber A, Dueñas M, Segovia C, Rubio C, Fernandez M, Villacampa F, Duarte J, López-Calderón FF, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM.
Clin Epigenetics. 2015 Oct 8;7:109. doi: 10.1186/s13148-015-0141-x. eCollection 2015.
PMID:26457124

Differential Features Between Chronic Skin Inflammatory Diseases Revealed in Skin-Humanized Psoriasis and Atopic Dermatitis Mouse Models.
Carretero M, Guerrero-Aspizua S, Illera N, Galvez V, Navarro M, García-García F, Dopazo J, Jorcano JL, Larcher F, Del Rio M.
J Invest Dermatol. 2015 Sep 23. doi: 10.1038/jid.2015.362.
PMID: 26398345

The downregulation of dNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.
Bornachea O, López-Calderón FF, Dueñas M, Segrelles C, Lorz C, Suárez-Cabrera C, Marañón M, Paradela-Dobarro B, Santos M, Paramio JM.
Oncotarget. 2015 Sep 15;6(27):24230-45.
PMID:26203771

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.
Kalathur M, Toso A, Chen J, Revandkar A, Danzer-Baltzer C, Guccini I, Alajati A, Sarti M, Pinton S, Brambilla L, Di Mitri D, Carbone G, Garcia-Escudero R, Padova A, Magnoni L, Tarditi A, Maccari L, Malusa F, Kalathur RK, A Pinna L, Cozza G, Ruzzene M, Delaleu N, Catapano CV, Frew IJ, Alimonti A.
Nat Commun. 2015 Jun 18;6:7227. doi: 10.1038/ncomms8227.
PMID: 26085373

Combined deletion of p38g and p38d reduces skin inflammation and protects from carcinogenesis.
Zur R, Garcia-Ibanez L, Nunez-Buiza A, Aparicio N, Liappas G, Escós A, Risco A, Page A, Saiz-Ladera C, Alsina-Beauchamp D, Montans J, Paramio JM, Cuenda A.
Oncotarget. 2015 May 30;6(15):12920-35. (PMID: 26079427)

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.
Palla AR, Piazzolla D, Alcazar N, Cañamero M, Graña O, Gómez-López G, Dominguez O, Dueñas M, Paramio JM, Serrano M.
Sci Rep. 2015 May 19;5:10205. doi: 10.1038/srep10205. (PMID: 25988972)

Interaction of CDCP1 with HER2 Enhances HER2-Driven Tumorigenesis and Promotes Trastuzumab Resistance in Breast Cancer.
Alajati A, Guccini I, Pinton S, Garcia-Escudero R, Bernasocchi T, Sarti M, Montani E, Rinaldi A, Montemurro F, Catapano C, Bertoni F, Alimonti A.
Cell Rep. 2015 Apr 28;11(4):564-76. doi: 10.1016/j.celrep.2015.03.044. Epub 2015 Apr 16.
PMID: 25892239

Excess NF-kB Induces Ectopic Odontogenesis in Embryonic Incisor Epithelium. Blackburn J, Kawasaki K, Porntaveetus T, Kawasaki M, Otsuka-Tanaka Y, Miake Y, Ota MS, Watanabe M, Hishinuma M, Nomoto T, Oommen S, Ghafoor S, Harada F, Nozawa-Inoue K, Maeda T, Peterková R, Lesot H, Inoue J, Akiyama T, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez Á, Sharpe PT, Ohazama A. J DENT RES January 2015 94: 121-128 PMID: 25376721

NOTCH pathway inactivation promotes bladder cancer progression.
Maraver A, Fernandez-Marcos PJ, Cash TP, Mendez-Pertuz M, Dueñas M, Maietta P, Martinelli P, Muñoz-Martin M, Martínez-Fernández M, Cañamero M, Roncador G, Martinez-Torrecuadrada JL, Grivas D, de la Pompa JL, Valencia A, Paramio JM, Real FX, Serrano M.
J Clin Invest. 2015 Jan 9. pii: 78185. doi: 10.1172/JCI78185.

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.
Di Mitri D, Toso A, Chen JJ, Sarti M, Pinton S, Jost TR, D'Antuono R, Montani E, Garcia-Escudero R, Guccini I, Da Silva-Alvarez S, Collado M, Eisenberger M, Zhang Z, Catapano C, Grassi F, Alimonti A.
Nature. 2014 Nov 6;515(7525):134-7. doi: 10.1038/nature13638. Epub 2014 Aug 24.
PMID: 25156255

Enhancing chemotherapy efficacy in pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Toso A, Revandkar A, Di Mitri D, Guccini I, Proietti M, Sarti M, Pinton S, Zhang J, Kalathur M, Civenni G, Jarrossay D, Montani E, Marini C, Garcia-Escudero R, Scanziani E, Grassi F, Pandolfi PP, Catapano CV, Alimonti A.
Cell Rep. 2014 Oct 9;9(1):75-89. doi: 10.1016/j.celrep.2014.08.044. Epub 2014 Sep 25.
PMID: 25263564

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.
Carnero A, Paramio JM.
Front Oncol. 2014 Sep 23;4:252. doi: 10.3389/fonc.2014.00252. eCollection 2014. Review.
PMID:25295225

Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors.
Contreras-Jurado C, García-Serrano L, Martínez-Fernández M, Ruiz-Llorente L, Paramio JM, Aranda A.
PLoS One. 2014 Sep 25;9(9):e108137. doi: 10.1371/journal.pone.0108137. eCollection PMID:25254665

In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.
Santos M, Martinez-Fernandez M, Duenas M, Garcia-Escudero R, Alfaya B, Villacampa F, Saiz-Ladera C, Costa C, Oteo M, Duarte J, Martinez V, Gomez-Rodriguez MJ, Martin ML, Fernandez M, Viatour P, Morcillo MA, Sage J, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Paramio JM.
Cancer Res. 2014 Sep 24. pii: canres.1218.2014. [Epub ahead of print]
PMID: 25252918

Akt Signalling Leads to Stem Cell Activation and Promotes Tumour Development in Epidermis.
Segrelles C, García-Escudero R, Garín MI, Aranda JF, Hernández P, Ariza JM, Santos M, Paramio JM, Lorz C.
Stem Cells 2014, 32(7):1917-28. doi: 10.1002/stem.1669.

RNAi-mediated knockdown of IKK1 in transgenic mice using a transgenic construct containing the human H1 promoter.
Moreno-Maldonado R, Murillas R, Navarro M, Page A, Suarez-Cabrera C, Alameda JP, Bravo A, Casanova ML, Ramírez A.
The Scientific World Journal. vol. 2014, Article ID 193803, 11 pages, 2014. doi:10.1155/2014/193803

Targeted silencing of DEFB4 in a bio-engineered skin-humanised mouse model for psoriasis: development of siRNA SECosome-based novel therapies.
Bracke S, Carretero M, Guerrero-Aspizua S, Desmet E, Illera N, Navarro M, Lambert J, Del Rio M.
Exp Dermatol. 2014 Jan 16. doi: 10.1111/exd.12321. [Epub ahead of print]
PMID: 24428418

2013

PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors.
Dueñas M, Martínez-Fernández M, García-Escudero R, Villacampa F, Marqués M, Saiz-Ladera C, Duarte J, Martínez V, Gómez MJ, Martín ML, Fernández M, Castellano D, Real FX, Rodriguez-Peralto JL, De La Rosa F, Paramio JM.
Mol Carcinog. 2013 Dec 18. doi: 10.1002/mc.22125. [Epub ahead of print]
PMID: 24347284

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.
Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM.
Oncogene. 2013 Oct 14. doi: 10.1038/onc.2013.417. [Epub ahead of print]
PMID: 24121270

Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis.
da Silva-Diz V, Solé-Sánchez S, Valdés-Gutiérrez A, Urpí M, Riba-Artés D, Penin RM, Pascual G, González-Suárez E, Casanovas O, Viñals F, Paramio JM, Batlle E, Muñoz P.
Oncogene. 2013 Aug 8;32(32):3732-43. doi: 10.1038/onc.2012.375. Epub 2012 Sep 3.
PMID: 22945646

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.
Menacho-Márquez M, García-Escudero R, Ojeda V, Abad A, Delgado P, Costa C, Ruiz S, Alarcón B, Paramio JM, Bustelo XR.
PLoS Biol. 2013 Jul;11(7):e1001615. doi: 10.1371/journal.pbio.1001615. Epub 2013 Jul 23.
PMID: 23935450

Functional inactivation of CYLD promotes the metastatic potential of tumor epidermal cells.
Alameda JP, Fernández-Aceñero MJ, Quintana RM, Page A, Ramírez Á, Navarro M, Casanova ML.
J Invest Dermatol. 2013 Jul;133(7):1870-8. doi: 10.1038/jid.2013.76. Epub 2013 Feb 20.
PMID: 23426135

E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis.
Costa C, Santos M, Martínez-Fernández M, Dueñas M, Lorz C, García-Escudero R, Paramio JM.
Oncogene. 2013 Jun 13;32(24):2937-51. doi: 10.1038/onc.2012.316. Epub 2012 Aug 13.
PMID: 22890321

The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.
Pérez-Gómez E, Andradas C, Flores JM, Quintanilla M, Paramio JM, Guzmán M, Sánchez C.
Oncogene. 2013 May 16;32(20):2534-42. doi: 10.1038/onc.2012.278. Epub 2012 Jul 2.
PMID: 22751111

Skin Tumors Rb(eing) Uncovered.
Costa C, Paramio JM, Santos M.
Front Oncol. 2013 Dec 17;3:307. eCollection 2013. Review.
PMID: 24381932

A transposon-based analysis of gene mutations related to skin cancer development.
Quintana RM, Dupuy AJ, Bravo A, Casanova ML, Alameda JP, Page A, Sánchez-Viera M, Ramírez A, Navarro M.
J Invest Dermatol. 2013 Jan;133(1):239-48. doi: 10.1038/jid.2012.245. Epub 2012 Jul 26.
PMID: 22832494

2012

Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland.
García-Zaragoza E, Pérez-Tavarez R, Ballester A, Lafarga V, Jiménez-Reinoso A, Ramírez A, Murillas R, Gallego MI.
Dev Biol. 2012 Dec 1;372(1):28-44. doi: 10.1016/j.ydbio.2012.09.005. Epub 2012 Sep 20.
PMID: 23000969

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.
Citterio C, Menacho-Márquez M, García-Escudero R, Larive RM, Barreiro O, Sánchez-Madrid F, Paramio JM, Bustelo XR.
Sci Signal. 2012 Oct 2;5(244):ra71. doi: 10.1126/scisignal.2002962.
PMID: 23033540

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes.
Pippa R, Espinosa L, Gundem G, García-Escudero R, Dominguez A, Orlando S, Gallastegui E, Saiz C, Besson A, Pujol MJ, López-Bigas N, Paramio JM, Bigas A, Bachs O.
Oncogene. 2012 Sep 20;31(38):4207-20. doi: 10.1038/onc.2011.582. Epub 2011 Dec 19.
PMID: 22179826

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaría D, Barbacid M.
EMBO J. 2012 May 30;31(11):2498-510. doi: 10.1038/emboj.2012.94. Epub 2012 Apr 13.
PMID: 22505032

A humanized mouse model of HPV-associated pathology driven by E7 expression.
Buitrago-Pérez Á, Hachimi M, Dueñas M, Lloveras B, Santos A, Holguín A, Duarte B, Santiago JL, Akgül B, Rodríguez-Peralto JL, Storey A, Ribas C, Larcher F, del Rio M, Paramio JM, García-Escudero R.
PLoS One. 2012;7(7):e41743. doi: 10.1371/journal.pone.0041743. Epub 2012 Jul 23.
PMID: 22911850

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes.
Dueñas M, Santos M, Aranda JF, Bielza C, Martínez-Cruz AB, Lorz C, Taron M, Ciruelos EM, Rodríguez-Peralto JL, Martín M, Larrañaga P, Dahabreh J, Stathopoulos GP, Rosell R, Paramio JM, García-Escudero R.
PLoS One. 2012;7(8):e42494. doi: 10.1371/journal.pone.0042494. Epub 2012 Aug 7.
PMID: 22880004

A novel tumor suppressor network in squamous malignancies.
Costa C, Santos M, Segrelles C, Dueñas M, Lara MF, Agirre X, Prosper F, García-Escudero R, Paramio JM.
Sci Rep. 2012;2:828. doi: 10.1038/srep00828. Epub 2012 Nov 9.
PMID: 23145321

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours.
Bornachea O, Santos M, Martínez-Cruz AB, García-Escudero R, Dueñas M, Costa C, Segrelles C, Lorz C, Buitrago A, Saiz-Ladera C, Agirre X, Grande T, Paradela B, Maraver A, Ariza JM, Prosper F, Serrano M, Sánchez-Céspedes M, Paramio JM.
Sci Rep. 2012;2:434. doi: 10.1038/srep00434. Epub 2012 May 31.
PMID: 22666537

2011

IKKß overexpression leads to pathologic lesions in stratified epithelia and exocrine glands and to tumoral transformation of oral epithelia.
Page A, Cascallana JL, Casanova ML, Navarro M, Alameda JP, Pérez P, Bravo A, Ramírez A.
Mol Cancer Res. 2011 Oct;9(10):1329-38. doi: 10.1158/1541-7786.MCR-11-0168. Epub 2011 Aug 5.
PMID: 21821676

CYLD regulates keratinocyte differentiation and skin cancer progression in humans.
Alameda JP, Fernández-Aceñero MJ, Moreno-Maldonado R, Navarro M, Quintana R, Page A, Ramírez A, Bravo A, Casanova ML.
Cell Death Dis. 2011 Sep 8;2:e208. doi: 10.1038/cddis.2011.82.
PMID: 21900959

The thyroid hormone receptors as modulators of skin proliferation and inflammation.
Contreras-Jurado C, García-Serrano L, Gómez-Ferrería M, Costa C, Paramio JM, Aranda A.
J Biol Chem. 2011 Jul 8;286(27):24079-88. doi: 10.1074/jbc.M111.218487.
pub 2011 May 12.
PMID: 21566120

Risk assessment in skin gene therapy: viral-cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors.
Almarza D, Bussadori G, Navarro M, Mavilio F, Larcher F, Murillas R.
Gene Ther. 2011 Jul;18(7):674-81. doi: 10.1038/gt.2011.12. Epub 2011 Mar 3.
PMID: 21368897

Establishment of a murine epidermal cell line suitable for in vitro and in vivo skin modelling.
Segrelles C, Holguín A, Hernández P, Ariza JM, Paramio JM, Lorz C.
BMC Dermatol. 2011 Apr 21;11:9. doi: 10.1186/1471-5945-11-9.
PMID: 21510892

The thyroid hormone receptors modulate the skin response to retinoids.
García-Serrano L, Gomez-Ferrería MA, Contreras-Jurado C, Segrelles C, Paramio JM, Aranda A.
PLoS One. 2011;6(8):e23825. doi: 10.1371/journal.pone.0023825. Epub 2011 Aug 17.
PMID: 21858227

Increased IKK¿ expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors.
Alameda JP, Moreno-Maldonado R, Fernández-Aceñero MJ, Navarro M, Page A, Jorcano JL, Bravo A, Ramírez Á, Casanova ML.
PLoS One. 2011;6(7):e21984. doi: 10.1371/journal.pone.0021984. Epub 2011 Jul 6.
PMID: 21755017

2010

An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells.
Alameda JP, Moreno-Maldonado R, Navarro M, Bravo A, Ramírez A, Page A, Jorcano JL, Fernández-Aceñero MJ, Casanova ML.
Oncogene. 2010 Dec 16;29(50):6522-32. doi: 10.1038/onc.2010.378. Epub 2010 Sep 13.
PMID: 20838385

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.
García-Escudero R, Martínez-Cruz AB, Santos M, Lorz C, Segrelles C, Garaulet G, Saiz-Ladera C, Costa C, Buitrago-Pérez A, Dueñas M, Paramio JM.
Mol Cancer. 2010 Jul 14;9:193. doi: 10.1186/1476-4598-9-193.
PMID: 20630075

Overexpression of connexin26 in the basal keratinocytes reduces sensitivity to tumor promoter TPA.
Wang X, Ramirez A, Budunova I.
Exp Dermatol. 2010 Jul 1;19(7):633-40. doi: 10.1111/j.1600-625.2009.01013.x.
Epub 2009 Dec 7.
PMID: 20002174

IKKbeta leads to an inflammatory skin disease resembling interface dermatitis.
Page A, Navarro M, Garín M, Pérez P, Casanova ML, Moreno R, Jorcano JL, Cascallana JL, Bravo A, Ramírez A.
J Invest Dermatol. 2010 Jun;130(6):1598-610. doi: 10.1038/jid.2010.28. Epub 2010 Mar 4.
PMID: 20200541

A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling.
Lorz C, García-Escudero R, Segrelles C, Garín MI, Ariza JM, Santos M, Ruiz S, Lara MF, Martínez-Cruz AB, Costa C, Buitrago-Pérez A, Saiz-Ladera C, Dueñas M, Paramio JM.
Stem Cell Rev. 2010 Jun;6(2):162-77. doi: 10.1007/s12015-010-9139-0.
PMID: 20376578

Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo.
Rubio R, García-Castro J, Gutiérrez-Aranda I, Paramio J, Santos M, Catalina P, Leone PE, Menendez P, Rodríguez R.
Cancer Res. 2010 May 15;70(10):4185-94. doi: 10.1158/0008-5472.CAN-09-4640. Epub 2010 May 4.
PMID: 20442289

In vivo transplantation of genetically modified mouse embryonic epidermis.
Martínez-Cruz AB, Costa C, Saiz C, Paramio JM, Santos M.
Methods Mol Biol. 2010;585:361-7. doi: 10.1007/978-1-60761-380-0_25.
PMID: 19908016

Gene expression profiling of mouse epidermal keratinocytes.
García-Escudero R, Paramio JM.
Methods Mol Biol. 2010;585:171-81. doi: 10.1007/978-1-60761-380-0_13.
PMID: 19908004

Isolation of adult mouse stem keratinocytes using magnetic cell sorting (MACS).
Lorz C, Segrelles C, Garín M, Paramio JM.
Methods Mol Biol. 2010;585:1-11. doi: 10.1007/978-1-60761-380-0_1.
PMID: 19907992

2009

C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Lopez RG, Garcia-Silva S, Moore SJ, Bereshchenko O, Martinez-Cruz AB, Ermakova O, Kurz E, Paramio JM, Nerlov C.
Nat Cell Biol. 2009 Oct;11(10):1181-90. doi: 10.1038/ncb1960. Epub 2009 Sep 13.
PMID: 19749746

Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma.
Moral M, Segrelles C, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Buitrago A, Costa C, Saiz C, Ariza JM, Dueñas M, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Digiovanni J, Paramio JM.
In Vivo. 2009 Sep-Oct;23(5):653-60.
PMID: 19779097

Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation.
Martínez-Cruz AB, Santos M, García-Escudero R, Moral M, Segrelles C, Lorz C, Saiz C, Buitrago-Pérez A, Costa C, Paramio JM.
Anticancer Res. 2009 Aug;29(8):3035-42.
PMID: 19661312

On the origin of epidermal cancers.
Lorz C, Segrelles C, Paramio JM.
Curr Mol Med. 2009 Apr;9(3):353-64. Review.
PMID: 19355916

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling.
Buitrago-Pérez A, Garaulet G, Vázquez-Carballo A, Paramio JM, García-Escudero R.
Curr Genomics. 2009 Mar;10(1):26-34. doi: 10.2174/138920209787581235.
PMID: 19721808

Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma.
Moral M, Segrelles C, Lara MF, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Kiguchi K, Buitrago A, Costa C, Saiz C, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Garín M, Grande T, Bravo A, DiGiovanni J, Paramio JM.
Cancer Res. 2009 Feb 1;69(3):1099-108. doi: 10.1158/0008-5472.CAN-08-3240. Epub 2009 Jan 27.
PMID: 19176372

Thyroid hormone receptor beta1 acts as a potent suppressor of tumor invasiveness and metastasis.
Martínez-Iglesias O, Garcia-Silva S, Tenbaum SP, Regadera J, Larcher F, Paramio JM, Vennström B, Aranda A.
Cancer Res. 2009 Jan 15;69(2):501-9. doi: 10.1158/0008-5472.CAN-08-2198.
PMID: 19147563

The analysis of intermediate filament dynamics using transfections and cell fusions.
Paramio JM.
Methods Mol Biol. 2009;586:357-65. doi: 10.1007/978-1-60761-376-3_20.
PMID: 19768441

2008

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.
Santos M, Ruiz S, Lara MF, Segrelles C, Moral M, Martínez-Cruz AB, Ballestín C, Lorz C, García-Escudero R, Paramio JM.
Mol Carcinog. 2008 Nov;47(11):815-21. doi: 10.1002/mc.20426.
PMID: 18300254

Akt pathway as a target for therapeutic intervention in HNSCC.
Moral M, Paramio JM.
Histol Histopathol. 2008 Oct;23(10):1269-78. Review.
PMID: 18712679

Gene expression profiling as a tool for basic analysis and clinical application of human cancer.
García-Escudero R, Paramio JM.
Mol Carcinog. 2008 Aug;47(8):573-9. doi: 10.1002/mc.20430.
PMID: 18324660

IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas.
Moreno-Maldonado R, Ramírez A, Navarro M, Fernández-Aceñero MJ, Villanueva C, Page A, Jorcano JL, Bravo A, Llanos Casanova M.
Cell Cycle. 2008 Jul 1;7(13):2021-9. Epub 2008 Apr 11.
PMID: 18604171

Transrepression function of the glucocorticoid receptor regulates eyelid development and keratinocyte proliferation but is not sufficient to prevent skin chronic inflammation.
Donet E, Bosch P, Sanchis A, Bayo P, Ramírez A, Cascallana JL, Bravo A, Pérez P.
Mol Endocrinol. 2008 Apr;22(4):799-812. doi: 10.1210/me.2007-0284. Epub 2008 Jan 3.
PMID: 18174358

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis.
Lara MF, García-Escudero R, Ruiz S, Santos M, Moral M, Martínez-Cruz AB, Segrelles C, Lorz C, Paramio JM.
Mol Carcinog. 2008 Mar;47(3):209-21.
PMID: 17932948

Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors.
Martínez-Cruz AB, Santos M, Lara MF, Segrelles C, Ruiz S, Moral M, Lorz C, García-Escudero R, Paramio JM.
Cancer Res. 2008 Feb 1;68(3):683-92. doi: 10.1158/0008-5472.CAN-07-3049.
PMID: 18245467

p107 acts as a tumor suppressor in pRb-deficient epidermis.
Lara MF, Santos M, Ruiz S, Segrelles C, Moral M, Martínez-Cruz AB, Hernández P, Martínez-Palacio J, Lorz C, García-Escudero R, Paramio JM.
Mol Carcinog. 2008 Feb;47(2):105-13.
PMID: 17932945

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.
Segrelles C, Moral M, Lorz C, Santos M, Lu J, Cascallana JL, Lara MF, Carbajal S, Martínez-Cruz AB, García-Escudero R, Beltran L, Segovia JC, Bravo A, DiGiovanni J, Paramio JM.
Mol Biol Cell. 2008 Jan;19(1):137-49. Epub 2007 Oct 24.
PMID: 17959825

2007

Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.
Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF, Rho O, Carbajal S, Traag J, Beltrán L, Martínez-Cruz AB, García-Escudero R, Lorz C, Ruiz S, Bravo A, Paramio JM, DiGiovanni J.
Cancer Res. 2007 Nov 15;67(22):10879-88.
PMID: 18006833

Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk.
Honda K, Sakaguchi T, Sakai K, Schmedt C, Ramirez A, Jorcano JL, Tarakhovsky A, Kamisoyama H, Sakai T.
Carcinogenesis. 2007 Oct;28(10):2074-81. Epub 2007 May 10.
PMID: 17494055

Modeling normal and pathological processes through skin tissue engineering.
Garcia M, Escamez MJ, Carretero M, Mirones I, Martinez-Santamaria L, Navarro M, Jorcano JL, Meana A, Del Rio M, Larcher F.
Mol Carcinog. 2007 Aug;46(8):741-5. Review.
PMID: 17610222

The Rb family connects with the Tp53 family in skin carcinogenesis.
Lara MF, Paramio JM.
Mol Carcinog. 2007 Aug;46(8):618-23. Review.
PMID: 17486638

The ends of a conundrum?.
Paramio JM, Santos M, Jorcano JL.
J Cell Sci. 2007 Apr 1;120(Pt 7):1145-7; author reply 1147-8. No abstract available.
PMID: 17376958